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HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phenobarbital reduced the… Expand
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Earlier studies showed that phenobarbital feeding enhanced hepatic tumorigenesis in rats previously fed 2-acetylaminofluorene for a brief period. As part of an investigation of the mechanism of this… Expand
Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
- C. Peraino, R. Fry, E. Staffeldt, J. Christopher
- Chemistry, Medicine
- Food and cosmetics toxicology
Abstract A comparison has been made between the enhancing effects of 0.05% dietary phenobarbitone and of 05% dietary butylated hydroxytoluene (BHT) on hepatic tumorigenesis in rats previously fed… Expand
Early appearance of histochemically altered hepatocyte foci and liver tumors in female rats treated with carcinogens one day after birth.
A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4… Expand
The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells.
N-(2-mercaptoethyl)-1,3-diaminopropane (WR1065) protects against radiation-induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in V79 Chinese… Expand
Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
In a previous study, phenobarbital feeding enhanced hepatic tumorigenesis in rats previously fed 2-acetylamino-fluorene (AAF). The present study analyzed this enhancement by comparing tumor… Expand
Systematic oscillations in metabolic activity in rat liver and in hepatomas. I. Morris hepatoma No. 7793.
Summary Environmentally induced changes in rat liver were used to determine the capability of a minimal deviation hepatoma (Morris hepatoma 7793) to respond to regulatory influences. Hepatomabearing… Expand
STUDIES ON THE INDUCTION AND REPRESSION OF ENZYMES IN RAT LIVER. I. INDUCTION OF THREONINE DEHYDRASE AND ORNITHINE-DELTA-TRANSAMINASE BY ORAL INTUBATION OF CASEIN HYDROLYSATE.
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day…
- C. Peraino, E. Staffeldt, B. Carnes, V. A. Ludeman, J. A. Blomquist, S. Vesselinovitch
- Biology, Medicine
- Cancer research
- 1 August 1984
A new experimental system was used to examine the stages of chemically induced hepatic neoplasia in the rat. The treatment protocol involved the i.p. injection of a single dose of carcinogen… Expand