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Estrogen receptor-dependent regulation of sensory neuron survival in developing dorsal root ganglion.
Estrogen is known to influence different functions in brain tissue ranging from neuronal development to plasticity and survival, but the mechanisms involved have not been defined clearly. PreviousExpand
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  • Open Access
Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.
The neuroblastoma cell line SK-ER3, which is stably transfected with the estrogen receptor (ER), was used to study the effect of insulin and insulin-like growth factors (IGF-I and IGF-II) on growthExpand
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Restorative effects of platelet derived growth factor-BB in rodent models of Parkinson's disease.
Parkinson's disease is characterized by motor deficits caused by loss of midbrain dopaminergic neurons. Neurotrophic factors and cell transplantation have partially restored function in models ofExpand
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Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells.
Insulin is a well known mitotic agent for neuroblastoma cells. Human SK-N-BE neuroblastoma cells stably transfected with the estrogen receptor, however, undergo growth arrest and differentiation whenExpand
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Divergent pathways regulate ligand-independent activation of ER alpha in SK-N-BE neuroblastoma and COS-1 renal carcinoma cells.
The alpha-estrogen receptor (ER alpha) transcriptional activity can be regulated either by binding to the cognate ligand or by intracellular signaling pathways responsive to a variety of factorsExpand
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Oestrogen Prevention of Neural Cell Death Correlates with Decreased Expression of mRNA for the Pro‐Apoptotic Protein Nip‐2
We have recently identified nip‐2 as a gene target for 17β‐oestradiol activity in the neuroblastoma SK‐ER3 cells expressing the oestrogen receptor (ER) α. Here we show 17β‐oestradiol treatment ofExpand
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Dopaminergic Phenotype Induced by Oestrogens in a Human Neuroblastoma Cell Line
Oestrogens are the key factor in the sexual differentiation of the mammalian brain and play an important role in the activity of selected areas of the mature brain. To pursue the study of oestrogenExpand
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Pituitary adenylate cyclase activating polypepetide is expressed by developing rat Purkinje cells and decreases the number of cerebellar γ-amino butyric acid positive neurons in culture
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) is expressed in various parts of the developing and adult rat brain, including the cerebellum. In situ hybridization wasExpand
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Estradiol induces differential neuronal phenotypes by activating estrogen receptor alpha or beta.
Estrogens are female sex steroids that have a plethora of effects on a wide range of tissues. These effects are mediated through two well characterized intracellular receptors: estrogen receptorExpand
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Estradiol Induces Differential Neuronal Phenotypes by Activating Estrogen Receptor α or β.
Estrogens are female sex steroids that have a plethora of effects on a wide range of tissues. These effects are mediated through two well characterized intracellular receptors: estrogen receptor αExpand
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