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THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
- C. Patlak, R. Blasberg, J. Fenstermacher
- BiologyJournal of cerebral blood flow and metabolism…
- 1 March 1983
A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer…
Random walk with persistence and external bias
- C. Patlak
- 1 September 1953
The partial differential equation of the random walk problem with persistence of direction and external bias is derived. By persistence of direction or internal bias we mean that the probability a…
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations
General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
Drainage of interstitial fluid from different regions of rat brain.
- I. Szentistványi, C. Patlak, R. A. Ellis, H. Cserr
- BiologyThe American journal of physiology
- 1 June 1984
RISA was concentrated in the subarachnoid space, relative to bulk CSF, in sleeves of adventitial tissue surrounding pericerebral arteries, possibly accounting for the low recovery of isotope from bulkCSF.
Efflux of radiolabeled polyethylene glycols and albumin from rat brain.
In efflux rate, despite a fivefold difference in diffusion coefficient, is consistent with convective losses from brain, and the maximal rate of interstitial fluid removal estimated on the basis of these data is 0.11 microliter.
Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
These studies indicated that the transport of AIB into brain cells was approximately 110 to 265 times greater than that across normal brain capillaries per unit mass of brain tissue, and that the BBB limits blood-to-brain cell transport of this amino acid.
Methods for Quantifying the transport of drugs across brain barrier systems.
Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion.
This work suggests that the exchange of these compounds between blood and brain is partially (water) or nearly completely (urea and ethylene glycol) limited to membrane permeability.