C. Patlak

Publications201
h-index56
Citations20,801
Highly Influential Citations658
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THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Abstract— A method has been developed for the simultaneous measurement of the rates of glucose consumption in the various structural and functional components of the brain in vivo. The method can be… Expand
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
TLDR
A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period. Expand
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Random walk with persistence and external bias
The partial differential equation of the random walk problem with persistence of direction and external bias is derived. By persistence of direction or internal bias we mean that the probability a… Expand
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations
  • C. Patlak, R. Blasberg
  • Mathematics, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 December 1985
The method of graphical analysis for the evaluation of sequential data (e.g., tissue and blood concentrations over time) in which the test substance is irreversibly trapped in the system has been… Expand
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Drainage of interstitial fluid from different regions of rat brain.
Studies were carried out in anesthetized rats comparing dynamics and pathways of interstitial fluid (ISF) drainage from different regions of brain. Rates of drainage from brain and flow into… Expand
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Efflux of radiolabeled polyethylene glycols and albumin from rat brain.
Experiments were carried out to evaluate the role of convection in the removal of large molecules from brain interstitial fluid. Radiolabeled test compounds were injected into the caudate nucleus of… Expand
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Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
The transport of α-aminoisobutyric acid (AIB), N-methyl-AIB (MeAIB), and diethylenetriaminepentaacetic acid (DTPA) from blood to brain was measured over different experimental periods in eight… Expand
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Nigrostriatal function in humans studied with positron emission tomography
The dopamine depletion that is characteristic of Parkinson's disease has been hypothesized to result from the combination of environmentally induced subclinical damage to the substantia nigra and the… Expand
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The flow of solute and solvent across a two-membrane system.
Abstract Equations are derived, utilizing the methods of irreversible thermodynamics, for the steady state flow of solvent and a single, neutral solute across a simple, non-homogeneous membrane… Expand
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Methods for Quantifying the transport of drugs across brain barrier systems.
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