Single‐Dose and Steady‐State Pharmacokinetics of Tomoxetine in Normal Subjects
- N. Farid, R. Bergstrom, E. Ziege, C. Parli, L. Lemberger
- MedicineJournal of clinical pharmacology
- 6 May 1985
A pharmacokinetic profile of tomoxetine, a selective norepinephrine uptake inhibitor, was developed in human volunteers following single and multiple oral administrations and appeared to have a bimodal distribution.
Analysis of the Enantiomers of Fluoxetine and Norfluoxetine in Plasma and Tissue Using Chiral Derivatization and Normal-Phase Liquid Chromatography
Abstract A stereospecific HPLC assay has been developed for the determination of the enantiomers of fluoxetine and an active metabolite, norfluoxetine, in plasma and tissue. Following derivatization…
In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A.
- B. Ring, C. Parli, M. George, S. Wrighton
- Biology, ChemistryDrug Metabolism And Disposition
- 1 May 1994
The monkey is better than the rat as a model for the exposure of humans to zatosetron and its metabolites, and the enzyme kinetics were determined using human, rat, and monkey hepatic microsomal incubations.
Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs.
- J. Gidda, D. C. Evans, M. Cohen, D. Wong, D. Robertson, C. Parli
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 May 1995
These studies suggest that, in dogs, antagonism of 5-HT3 receptors located within the blood-brain barrier is important to block cisplatin-induced emesis.
Preclinical studies on LY237733, a potent and selective serotonergic antagonist.
- M. Foreman, R. Fuller, C. Parli
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1992
The in vitro radioligand displacement studies showed that LY237733 has a preferential affinity for 5-HT1c and5-HT2 receptors compared to other monoaminergic receptors, which has provided the pre-clinical rationale to evaluate the effects of this compound in the treatment of sexual disorders such as psychogenic erectile dysfunction, and other therapeutic indications for a 5- HT2 antagonist, including depression, anxiety, schizophrenia and migraine.
Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant.
- D. Robertson, E. Beedle, J. Leander
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 April 1991
Data indicate that 7 is a major metabolite of ameltolide, but does not contribute significantly to the pharmacological effects seen after administration of ametolide to mice, suggesting that these data reflect intrinsic pharmacological activities.
Induction of drug metabolism. IV. Relative abilities of polycyclic hydrocarbons to increase levels of microsomal 3-methyl-4-methylaminoazobenzene N-demethylase activity and cytochrome P1-450.
- C. Parli, G. Mannering
- Chemistry, BiologyMolecular Pharmacology
- 1 March 1970
When a maximally stimulatory dose of a polycyclic hydrocarbon was given, it caused finite increases in microsomal 3-methyl-4-methylaminoazobenzene N -demethylase activity and cytochrome P 1 -450 content, whether it was a poor, intermediate, or potent inducing agent.
Preclinical pharmacology of metkephamid (LY127623), a Met-enkephalin analogue.
- R. Frederickson, C. Parli, G. Devane, M. Hynes
- BiologyNIDA research monograph
- 1 April 1983
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