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Structure-Activity Relationships of Components from the Roots of Pueraria thunbergiana Having Aldose Reductase Inhibitory and Antioxidative Activity
but their inhibitory activities on aldose reductasehave not yet been reported. Aldose reductase (AR), the keyenzyme of the polyol pathway, has been demonstrated toplay an important role in theExpand
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Bone density measurement in interdental areas with simulated placement of orthodontic miniscrew implants.
INTRODUCTION The purposes of this study were to determine bone density at various orthodontic implant sites and compare them according to depth and area (anterior and posterior, buccal and lingual,Expand
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KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement
AbstractsCore binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospectiveExpand
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Congenital Zinc Deficiency from Mutations of the SLC39A4 Gene as the Genetic Background of Acrodermatitis Enteropathica
Acrodermatitis enteropathica (AE) is an autosomal recessive disorder with the clinical triad of acral dermatitis, diarrhea and alopecia. AE is known to be caused by mutations of the SLC39A4 gene onExpand
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Prevalence and clinical significance of occult hepatitis B virus infection among renal transplant recipients in Korea
Abstract Background: Occult hepatitis B infection (OBI) is the presence of hepatitis B virus (HBV) DNA in serum or hepatic tissue without detectable hepatitis B surface antigen (HBsAg) in serum.Expand
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Sequence Variations and Haplotypes of the GJB2 Gene Revealed by Resequencing of 192 Chromosomes from the General Population in Korea
  • H. Kim, C. Park, +8 authors S. Hong
  • Biology, Medicine
  • Clinical and experimental otorhinolaryngology
  • 1 June 2010
Objectives Hearing impairment (HI) is the most common sensory deficit in human. The Gap Junction Protein, Beta-2 (GJB2) gene encodes the protein connexin 26, and this gene accounts for up to half ofExpand
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High frequency of JAK2 exon 12 mutations in Korean patients with polycythaemia vera: novel mutations and clinical significance
Gain-of-function mutations in JAK2 are the molecular hallmarks of polycythaemia vera (PV), one of the myeloproliferative neoplasms. Most (∼95%) patients harbour V617F mutation in exon 15, while theExpand
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Genetic Polymorphisms Associated with 5-Fluorouracil-Induced Neurotoxicity
Background: Encephalopathy is a rare drug toxicity of fluorouracil therapy. Toxicity from fluorouracil therapy is known to be associated with the individual genetic background of the enzymes,Expand
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Antimutagenic activity of 5α-cholest-7-en-3β-ol, a new component from the starfish Asterina pectinifera
From the butanol fraction of the starfish Asterina pectinifera MULER et TROSCHEL (Asteriidae), we have isolated a new component, 5α-cholest-7-en-3β-ol. Its antigenotoxic and antimutagenic activitiesExpand
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Diagnostic Utility of a Multiplex RT-PCR Assay in Detecting Fusion Transcripts From Recurrent Genetic Abnormalities of Acute Leukemia by WHO 2008 Classification
Fusion transcripts (FT) from chromosomal rearrangements are key culprits in acute leukemia, with genotype-phenotype correlations including prognostic implications. Here, we report our experience of aExpand
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