• Publications
  • Influence
STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
Store-operated Ca(2+) channels activated by the depletion of Ca(2+) from the endoplasmic reticulum (ER) are a major Ca(2+) entry pathway in nonexcitable cells and are essential for T cell activationExpand
  • 785
  • 96
Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previouslyExpand
  • 539
  • 34
  • PDF
Pathogen- and NaCl-Induced Expression of the SCaM-4 Promoter Is Mediated in Part by a GT-1 Box That Interacts with a GT-1-Like Transcription Factor1
The Ca2+-binding protein calmodulin mediates cellular Ca2+ signals in response to a wide array of stimuli in higher eukaryotes. Plants express numerous CaM isoforms. Transcription of one soybeanExpand
  • 306
  • 22
  • PDF
STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels
Ca2+-dependent inactivation (CDI) is a key regulator and hallmark of the Ca2+ release-activated Ca2+ (CRAC) channel, a prototypic store-operated Ca2+ channel. Although the roles of the endoplasmicExpand
  • 216
  • 20
  • PDF
Collective cell guidance by cooperative intercellular forces
Cells comprising a tissue migrate as part of a collective. How collective processes are coordinated over large multi-cellular assemblies has remained unclear, however, because mechanical stressesExpand
  • 438
  • 19
  • PDF
The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels
Channel STIMulation The STIM1 protein functions as a calcium sensor and regulates entry of calcium into cells across the plasma membrane. When cell surface receptors are stimulated and cause releaseExpand
  • 244
  • 19
Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistance responses.
  • W. Heo, S. Lee, +8 authors M. Cho
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 January 1999
The Ca2+ signal is essential for the activation of plant defense responses, but downstream components of the signaling pathway are still poorly defined. Here we demonstrate that specific calmodulinExpand
  • 233
  • 18
WRKY group IId transcription factors interact with calmodulin
Calmodulin (CaM) is a ubiquitous Ca2+‐binding protein known to regulate diverse cellular functions by modulating the activity of various target proteins. We isolated a cDNA encoding AtWRKY7, a novelExpand
  • 156
  • 17
Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences largeExpand
  • 228
  • 12
  • PDF