Hypotonicity Induces TRPV4-Mediated Nociception in Rat
Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
Transient Receptor Potential Vanilloid 4 Is Essential in Chemotherapy-Induced Neuropathic Pain in the Rat
- N. Alessandri‐Haber, O. A. Dina, J. Yeh, C. Parada, D. Reichling, J. Levine
- BiologyJournal of Neuroscience
- 5 May 2004
The results suggest that TRPV4 plays a crucial role in a painful peripheral neuropathy, making it a very promising target for the development of a novel class of analgesics.
Development of a behavioral model of TMJ pain in rats: the TMJ formalin test
Crucial role of neutrophils in the development of mechanical inflammatory hypernociception
During the inflammatory process, the migrating neutrophils participate in the cascade of events leading to mechanical hypernociception, at least by mediating the release of direct‐acting hypernOCiceptive mediators, such as PGE2.
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception
The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA
An electronic pressure-meter nociception paw test for mice.
The present results validate the use of the electronic pressure-meter as more sensitive than the von Frey filaments for the detection of the increase in nociception induced by small doses of carrageenin and the antinociceptive effect of non-steroidal drugs in a dose-dependent manner.
Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion
- D. Araldi, L. Ferrari, C. Parada
- Biology, MedicineProceedings of the National Academy of Sciences
- 11 February 2013
The results of this study suggest that the inflammatory hyperalgesia in peripheral tissue depends on activation of COX-1 andCOX-2 in C-fibers, which contribute to the induction and maintenance of sensitization of primary sensory neurons.