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Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat: isolation and characterization of new metabolites.
1. The metabolic disposition of R-(+)-pulegone (I) was examined in rats following four daily oral doses (250 mg/kg). 2. Six metabolites, namely pulegol (II),… Expand
Metabolic fate of menthofuran in rats. Novel oxidative pathways.
- K. M. Madyastha, C. P. Raj
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 March 1992
Metabolic fate of menthofuran (II) in rats was investigated. Menthofuran (II) was administered orally (200 mg/kg of the body weight/day) to rats for 3 days. The following metabolites were isolated… Expand
Biotransformations of R-(+)-pulegone and menthofuran in vitro: chemical basis for toxicity.
Incubation of R-(+)-pulegone(I) with PB-induced rat liver microsomes in the presence of NADPH resulted in the formation of menthofuran (II) and 2-Z-[2'-keto-4'-methylcyclohexylidene] propanol (III,… Expand
Evidence for the formation of a known toxin, p-cresol, from menthofuran.
Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary… Expand
Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo.
Oral administration (250 mg/kg) of menthofuran, a monoterpene furan, to rats once daily for 3 days caused hepatotoxicity as judged by a significant increase in serum glutamate pyruvate transaminase… Expand
Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.
R-(+)-Pulegone, a monoterpene ketone, is a potent hepatotoxin. One of the major metabolites of pulegone has been shown to be p-cresol, a glutathione depletor and a known toxin. Allylic hydroxylation… Expand
Synthesis of Conjugated Diallenes by Double [2,3]‐Sigmatropic Rearrangement of Conjugated Diyne Trichloromethanesulfenates.
Synthesis of Exocyclic cisoid Dienes by Ramberg—Baecklund Rearrangement.
Synthesis of exocyclic cisoid dienes by Ramberg–Bäcklund rearrangement
Abstract Bicyclic and monocyclic cisoid dienes were synthesized by an amine-catalyzed Ramberg–Backlund rearrangement of allylic trichloromethyl sulfones, in good yields.