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Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat: isolation and characterization of new metabolites.
1. The metabolic disposition of R-(+)-pulegone (I) was examined in rats following four daily oral doses (250 mg/kg). 2. Six metabolites, namely pulegol (II),Expand
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Metabolic fate of menthofuran in rats. Novel oxidative pathways.
Metabolic fate of menthofuran (II) in rats was investigated. Menthofuran (II) was administered orally (200 mg/kg of the body weight/day) to rats for 3 days. The following metabolites were isolatedExpand
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Biotransformations of R-(+)-pulegone and menthofuran in vitro: chemical basis for toxicity.
Incubation of R-(+)-pulegone(I) with PB-induced rat liver microsomes in the presence of NADPH resulted in the formation of menthofuran (II) and 2-Z-[2'-keto-4'-methylcyclohexylidene] propanol (III,Expand
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Evidence for the formation of a known toxin, p-cresol, from menthofuran.
Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinaryExpand
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Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo.
Oral administration (250 mg/kg) of menthofuran, a monoterpene furan, to rats once daily for 3 days caused hepatotoxicity as judged by a significant increase in serum glutamate pyruvate transaminaseExpand
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Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.
R-(+)-Pulegone, a monoterpene ketone, is a potent hepatotoxin. One of the major metabolites of pulegone has been shown to be p-cresol, a glutathione depletor and a known toxin. Allylic hydroxylationExpand
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Synthesis of exocyclic cisoid dienes by Ramberg–Bäcklund rearrangement
Abstract Bicyclic and monocyclic cisoid dienes were synthesized by an amine-catalyzed Ramberg–Backlund rearrangement of allylic trichloromethyl sulfones, in good yields.
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