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Dextromethorphan reduces neocortical ischemic neuronal damage in vivo
The dextrorotatory morphinan dextromethorphan (DM), a clinically tested antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, was tested in an in vivo model of acute transient focal… Expand
Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits.
We investigated dextromethorphan, both a dextrorotatory opioid derivative and a clinically tested N-methyl-D-aspartate (NMDA) receptor antagonist, in a rabbit model of transient focal cerebral… Expand
Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex
- N. Shimada, R. Graf, G. Rosner, A. Wakayama, C. P. George, W. Heiss
- Chemistry, Medicine
- Journal of cerebral blood flow and metabolism…
- 1 October 1989
Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of… Expand
Acute cerebral ischemia in rabbits: correlation between MR and histopathology.
- R. DeLaPaz, D. Shibata, G. Steinberg, R. Zarnegar, C. P. George
- AJNR. American journal of neuroradiology
The histologic description of cerebral ischemia is complex, and within most lesions there are regional variations in degrees of neuronal cell injury, edema, and neuropil disruption. These parameters… Expand
Autoradiographic patterns of hippocampal metabolism during induced hypothermia
- C. P. George, T. Kilduff, F. Sharp, H. Heller
- Chemistry, Medicine
- Neuroscience Letters
- 31 December 1982
[14C]2-Deoxyglucose (2-DG) uptake in the hippocampal formation was studied in the ground squirrel subjected to induced hypothermia. Whereas the stratum lacunosum-molecular has the highest 2-DG uptake… Expand
Metabolic activation of the brachium conjunctivum during induced hypothermia
During hypothermia induced in ground squirrels by the halothane-heliox method, 2-deoxyglucose uptake of a white matter structure, the brachium conjunctivum, increased relative to the surrounding gray… Expand