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Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.
TLDR
It is demonstrated that interactions between Hox and Pbx proteins modulate their DNA-binding properties, suggesting that PbX and Hox proteins act in parallel as heterotypic complexes to regulate expression of specific subordinate genes. Expand
Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins
TLDR
It is concluded that Meis proteins are preferred in vivo DNA binding partners for wild-type Pbx1, a relationship that is circumvented by its oncogenic counterpart E2a-PbX1. Expand
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.
TLDR
The purification of a complex of at least 10 VDR interacting proteins (DRIPs) ranging from 65 to 250 kD that associate with the receptor in a strictly 1,25-dihydroxyvitamin D3-dependent manner are described, demonstrating the existence of a new complex of novel functional nuclear receptor coactivators. Expand
Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus
TLDR
Interactions with Pbx were found to play an essential role in modulating Hox homeodomain amino-terminal arm contact with DNA in the core of the Hox half site such that heterodimers of different compositions could distinguish single nucleotide alterations in the H Cox half site both in vitro and in cellular assays measuring transactivation. Expand
A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection
TLDR
The long inverted repeat and the adjacent sequences are major early transcription sites of the human cytomegalovirus genome and an early transcription unit which flanks the large terminal repeat was analyzed by RNA mapping at various times after infection. Expand
Escherichia coli secretion of an active chimeric antibody fragment.
TLDR
The production in Escherichia coli of foreign heterodimeric protein reagents, such as Fab, should prove useful in the management of human disease. Expand
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.
TLDR
Ligand-induced internalization of epidermal growth factor receptors via a high affinity saturable pathway requires sequences located in the carboxyl terminus distal to the tyrosine kinase domain to contain endocytic motifs that are exchangeable between ligand-dependent and -independent receptors. Expand
Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.
TLDR
The data suggest that the structural features of Hox proteins which determine Hox-Pbx1a-DNA complex stability reside within the precise structural relationships between the homeodomain, hexapeptide and linker regions. Expand
The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis
TLDR
Interactions mediated by the HCM are more important for transformation by E2a-Pbx1 than interactions with cognate Pbx DNA sites. Expand
Identification and expression of a human cytomegalovirus early glycoprotein
TLDR
A human cytomegalovirus early gene which possesses three temporally regulated promoters is located in the large unique component of the viral genome between 0.054 and 0.064 map units and is considered an early structural glycoprotein. Expand
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