C. Owman

Publications518
h-index70
Citations21,375
Highly Influential Citations408
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Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.
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Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells
TLDR
The CHO cells with stably transfected adenosine receptors provide an identical cellular background for such a pharmacological characterization and are valuable systems for further characterization of specific receptor subtypes and for the development of new ligands.
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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
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Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
TLDR
The ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied and it was found that it is the most abundant GPCR activated by LPA found in the small intestinal intraepithelial CD8+ cytotoxic T cells.
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Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
TLDR
The findings show that GPR30 is important for several metabolic functions in female mice, including estradiol-stimulated insulin release, which is associated with decreased insulin expression and release in vivo and in vitro in isolated pancreatic islets.
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Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system
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Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues.
TLDR
Receptor message was ubiquitously distributed in normal peripheral tissues and CNS, suggesting that CMKRL2 is expressed in widespread cell populations, such as macrophages and neuroglia.
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Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study
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Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging.
TLDR
The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values and a nightly peak production approximately 0200 h of 42 +/- 2 ml/h.
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Coevolution of RANTES Sensitivity and Mode of CCR5 Receptor Use by Human Immunodeficiency Virus Type 1 of the R5 Phenotype
TLDR
The results indicate a close relationship between HIV-1 phenotypic changes and the pathogenic process, since the mode and efficiency of CCR5 use as well as the decrease in the RANTES sensitivities of isolated viruses are significantly correlated with CD4+-T-cell decline in a patient.
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