• Publications
  • Influence
The cell biology of leukocyte‐mediated proteolysis
Leukocyte‐derived proteinases have the capacity to degrade every component of the extracellular matrix, and thereby play fundamental roles in physiological processes. However, if the activity ofExpand
  • 414
  • 27
Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases
Serine proteinases of human polymorphonuclear neutrophils play an important role in neutrophil-mediated proteolytic events; however, the non-oxidative mechanisms by which the cells can degradeExpand
  • 382
  • 21
  • PDF
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.
BACKGROUND Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is possible that a normalExpand
  • 334
  • 19
  • PDF
Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase1
Little is known about the cell biology or the biologic roles of polymorphonuclear cell (PMN)-derived matrix metalloproteinase-8 (MMP-8). When activated with proinflammatory mediators, human PMNExpand
  • 248
  • 14
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, andExpand
  • 215
  • 13
  • PDF
CD8+ T Cells Are Required for Inflammation and Destruction in Cigarette Smoke-Induced Emphysema in Mice1
Increased numbers of T lymphocytes are observed in the lungs of patients with chronic obstructive pulmonary disease, but their role in the disease process is not known. We investigated the role ofExpand
  • 216
  • 13
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as the consequence ofExpand
  • 293
  • 12
  • PDF
Bioactive Proteinase 3 on the Cell Surface of Human Neutrophils: Quantification, Catalytic Activity, and Susceptibility to Inhibition1
Although proteinase 3 (PR3) is known to have the potential to promote inflammation and injure tissues, the biologic forms and function of PR3 in polymorphonuclear neutrophils (PMN) from healthyExpand
  • 193
  • 11
Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease
  • C. Owen
  • Medicine
  • International journal of chronic obstructive…
  • 1 June 2008
Since the early 1960s, a compelling body of evidence has accumulated to show that proteinases play critical roles in airspace enlargement in chronic obstructive pulmonary disease (COPD). However,Expand
  • 131
  • 8
  • PDF
Protective role for club cell secretory protein-16 (CC16) in the development of COPD
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We measured CC16Expand
  • 74
  • 8
...
1
2
3
4
5
...