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A common toxin fold mediates microbial attack and plant defense
Many plant pathogens secrete toxins that enhance microbial virulence by killing host cells. Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In contrast,Expand
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Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy.
Regulatory 14-3-3 proteins activate the plant plasma membrane H(+)-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III,Expand
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Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3
Subtilases are serine proteases found in Archae, Bacteria, yeasts, and higher eukaryotes. Plants possess many more of these subtilisin-like endopeptidases than animals, e.g., 56 identified genes inExpand
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Phosphorylation‐independent interaction between 14‐3‐3 and exoenzyme S: from structure to pathogenesis
14‐3‐3 proteins are phosphoserine/phosphothreonine‐recognizing adapter proteins that regulate the activity of a vast array of targets. There are also examples of 14‐3‐3 proteins binding their targetsExpand
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Molecular tweezers modulate 14-3-3 protein-protein interactions.
Supramolecular chemistry has recently emerged as a promising way to modulate protein functions, but devising molecules that will interact with a protein in the desired manner is difficult as manyExpand
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A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Small-molecule stabilization of protein-protein interactions is an emerging field in chemical biology. We show how fusicoccanes, originally identified as fungal toxins acting on plants, promote theExpand
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Identification of an allosteric binding site for RORγt inhibition
RORγt is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases. We report the discovery of a novel allosteric binding site on theExpand
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Protein-Protein Interactions.
  • C. Ottmann
  • Chemistry, Medicine
  • Drug discovery today. Technologies
  • 1 June 2017
EDITORIAL Protein–Protein Interactions Christian Ottmann Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University ofExpand
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Structural insights of the MLF1/14‐3‐3 interaction
Myeloid leukaemia factor 1 (MLF1) binds to 14‐3‐3 adapter proteins by a sequence surrounding Ser34 with the functional consequences of this interaction largely unknown. We present here theExpand
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Involvement of 14‐3‐3 in tubulin instability and impaired axon development is mediated by Tau
14‐3‐3 proteins act as adapters that exert their function by interacting with their various protein partners. 14‐3‐3 proteins have been implicated in a variety of human diseases includingExpand
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