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INFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and…
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
It is concluded that Type 2 diabetes and hypertension have a common origin in sub-optimal development in utero, and that syndrome X should perhaps be re-named “the small-baby syndrome”.
Fetal origins of adult disease: strength of effects and biological basis.
- D. Barker, J. Eriksson, T. Forsén, C. Osmond
- MedicineInternational journal of epidemiology
- 1 December 2002
The combination of small size at birth and during infancy, followed by accelerated weight gain from age 3 to 11 years, predicts large differences in the cumulative incidence of CHD, type 2 diabetes and hypertension.
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease.
In national samples of 10 year olds and adults in Britain systolic blood pressure was inversely related to birth weight, which suggests that the intrauterine environment influences blood pressure during adult life.
Fetal and infant growth and impaired glucose tolerance at age 64.
Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants
Trajectories of growth among children who have coronary events as adults.
- D. Barker, C. Osmond, T. Forsén, E. Kajantie, J. Eriksson
- MedicineThe New England journal of medicine
- 27 October 2005
On average, adults who had a coronary event had been small at birth and thin at two years of age and thereafter put on weight rapidly and was associated with insulin resistance in later life.