• Publications
  • Influence
Pharmacological consequences of oxidative stress in ocular tissues.
The eye is a unique organ because of its constant exposure to radiation, atmospheric oxygen, environmental chemicals and physical abrasion. That oxidative stress mechanisms in ocular tissues haveExpand
  • 131
  • 4
Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX)
A growing body of evidence demonstrates the efficacy of Garcinia cambogia-derived natural (–)-hydroxycitric acid (HCA) in weight management by curbing appetite and inhibiting body fat biosynthesis.Expand
  • 100
  • 2
Effect of Hydrogen Sulfide on Sympathetic Neurotransmission and Catecholamine Levels in Isolated Porcine Iris-Ciliary Body
In the present study, we investigated the pharmacological action of hydrogen sulfide (H2S, using sodium hydrosulfide, NaHS, and/or sodium sulfide, Na2S as donors) on sympathetic neurotransmissionExpand
  • 62
  • 2
Inhibition of Potassium- and Ischemia-Evoked [3H] D-Aspartate Release from Isolated Bovine Retina by Cannabinoids
We investigated the effect of cannabinoids on potassium chloride (K+)- and ischemia-induced [3H]D-aspartate release from isolated bovine retinae. The superfusion method was employed for studies ofExpand
  • 25
  • 2
Lipid peroxidation: pathophysiological and pharmacological implications in the eye
Oxygen-derived free radicals such as hydroxyl and hydroperoxyl species have been shown to oxidize phospholipids and other membrane lipid components leading to lipid peroxidation. In the eye, lipidExpand
  • 38
  • 2
Effect of Isoprostanes on Sympathetic Neurotransmission in the Human Isolated Iris-Ciliary Body
Isoprostanes (IsoP's) are prostaglandin-like compounds that are derived from free-radical catalyzed peroxidation of arachidonic acid independent of the cyclcooxygenase enzyme. In the present study,Expand
  • 16
  • 2
Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye
Hydrogen sulfide (H2S) is a novel gasotransmitter with physiological and pathological functions in vascular homeostasis, cardiovascular system and central nervous system. In the present study, weExpand
  • 22
  • 1
Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes
Isoprostanes (IsoP) are formed by free radical catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. In the present study, we examined the effect of IsoP onExpand
  • 14
  • 1
Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae
We have previously shown that hydrogen peroxide (H 2 O 2) can inhibit K + -depolarization-evoked [ 3 H]D-aspartate release from bovine isolated retinae. In the present study, we investigated the roleExpand
  • 10
  • 1
Dual Effect of Isoprostanes on the Release of [3H]D-Aspartate from Isolated Bovine Retinae: Role of Arachidonic Acid Metabolites
The effect of 8-isoprostanes on potassium (K+)-depolarization-evoked release of [3H]D-aspartate from bovine isolated retinae was investigated. Isolated bovine retinae were prepared for studies ofExpand
  • 18
  • 1