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Phenotypic grouping of 141 BmNPVs lacking viral gene sequences.
TLDR
In a subsequent analysis of the properties needed for infection using a marker gene, egfp (enhanced green fluorescent protein gene), inserted into the polyhedrin locus, the knockout viruses (KOVs) were subdivided into four phenotypic types, A to D. Expand
Expression of MicroRNA miR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus
TLDR
Evaluating the importance of miR-122 on the replication of HCV in nonhepatic cells concluded that factors other than miD-122, which are most likely specific to hepatocytes, are required for HCV assembly. Expand
Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus
TLDR
Buoyant density gradient analysis revealed that HCV utilizes these lipoprotein receptors in a manner dependent on the lipoproteins associated with HCV particles. Expand
Establishment of a Novel Permissive Cell Line for the Propagation of Hepatitis C Virus by Expression of MicroRNA miR122
TLDR
The establishment of the new permissive cell line for HCVcc will have significant implications not only for basic HCV research but also for the development of new therapeutics. Expand
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome
TLDR
It is found that patients diagnosed with CRS from sepsis, acute respiratory distress syndrome (ARDS), or burns showed common manifestations of strikingly elevated levels of the four proinflammatory cytokines interleukin (IL)-6, IL-8, monocyte chemotactic protein-1 (MCP-1), and IL-10 and the coagulation cascade activator plasminogen activator inhibitors (PAI-1). Expand
Characterization of miR-122-independent propagation of HCV
TLDR
The results suggest that the emergence of HCV mutants that can propagate in non-hepatic cells in an miR-122-independent manner may participate in the induction of extra hepatic manifestations in chronic hepatitis C patients. Expand
Baculovirus: an insect-derived vector for diverse gene transfer applications.
TLDR
This review summarizes the advantages and current status of baculovirus-mediated gene delivery in stem cell transduction, preclinical animal studies, tissue engineering, vaccination, cancer gene therapy, viral vector production, and drug discovery. Expand
Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles
TLDR
Results suggest that amphipathic α-helices in the exchangeable apolipoproteins play crucial roles in the infectious particle formation of HCV and provide clues to the understanding of life cycle ofHCV and the development of novel anti-HCV therapeutics targeting for viral assembly. Expand
TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
TLDR
Oral administration of the SPP inhibitor to transgenic mice expressing HCV core protein (CoreTg) reduces the expression of core protein and ameliorates insulin resistance and liver steatosis and suggests that HCV utilizes SPP cleavage to circumvent the induction of ER stress in host cells. Expand
Various miRNAs compensate the role of miR-122 on HCV replication
TLDR
Structural modeling indicated that both miR-122-like and non-miR- 122-like miRNAs not only can facilitate the formation of an HCV IRES SLII but also can stabilize IRES 3D structure in order to facilitate binding of SLIII to the ribosome. Expand
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