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AFM indentation study of breast cancer cells.
TLDR
Atomic force microscopy indentation using a micro-sized spherical probe was carried out to characterize the elasticity of benign and cancerous human breast epithelial cells, showing a significant difference in the organization of their sub-membrane actin structures which directly contribute to their difference in cell elasticity. Expand
Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase*
TLDR
To their surprise, 3-MA is found to promote autophagy flux when treated under nutrient-rich conditions with a prolonged period of treatment, whereas it is still capable of suppressing starvation-induced autophagosomes or lysosomal function. Expand
Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries
TLDR
A workgroup of international experts and health officials convened in Geneva, Switzerland, in July 2005 identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies. Expand
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats.
TLDR
It is demonstrated that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs, points to significant effects on genes related to detoxification, lipid metabolism, cell cycle, defense response, and circadian rhythm. Expand
Antioxidant activity and profiles of common fruits in Singapore
Thirty-eight types of fruits commonly consumed in Singapore were systematically analysed for their hydrophilic oxygen radical absorbance capacity (H-ORAC), total phenolic content (TPC), ascorbic acidExpand
Critical Role of Reactive Oxygen Species and Mitochondrial Permeability Transition in Microcystin‐Induced Rapid Apoptosis in Rat Hepatocytes
TLDR
It is concluded that the M‐LR–induced ROS formation leads to the onset of MPT and apoptosis, and a specific MPT inhibitor, cyclosporin A (CsA), prevented the increase of ROS production, delayed the onsetof MPT, and, subsequently, cell death. Expand
Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes.
TLDR
Investigation of the effects of microcystic cyanobacteria extract collected from a contaminated water source on the organization of cellular microtubules and microfilaments in hepatocytes suggests that intracellular GSH plays an important role in MCE-induced cytotoxicity and cytoskeleton changes in primary cultured rat hepatocytes. Expand
CRITICAL ROLE OF REACTIVE OXYGEN SPECIES FORMATION IN MICROCYSTIN-INDUCED CYTOSKELETON DISRUPTION IN PRIMARY CULTURED HEPATOCYTES
TLDR
The results indicate that M-LR initiated reactive oxygen species (ROS) formation followed by altering the cytoskeleton structures, which eventually led to significant LDH leakage, which provides further evidence that ROS formation, especially superoxide radical, plays a crucial role in M- LR-induced disruption of cytos skeleton organization and consequent hepatotoxicity. Expand
Antioxidant activity and profiles of common vegetables in Singapore
Abstract Sixty-six types of vegetables commonly consumed in Singapore were analysed for their hydrophilic oxygen radical absorbance capacity (H-ORAC), total phenolic content (TPC), ascorbic acid (AA)Expand
Anti‐cancer properties of anthraquinones from rhubarb
TLDR
Re‐evaluation of an old remedy suggests that several bioactive anthraquinones of rhubarb possess promising anti‐cancer properties and could have a broad therapeutic potential. Expand
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