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AFM indentation study of breast cancer cells.
Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase*
To their surprise, 3-MA is found to promote autophagy flux when treated under nutrient-rich conditions with a prolonged period of treatment, whereas it is still capable of suppressing starvation-induced autophagosomes or lysosomal function.
Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries
- H. Strosnider, E. Azziz-Baumgartner, David P. Wilson
- MedicineEnvironmental Health Perspectives
- 24 August 2006
A workgroup of international experts and health officials convened in Geneva, Switzerland, in July 2005 identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies.
Antioxidant activity and profiles of common fruits in Singapore
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats.
Antioxidant activity and profiles of common vegetables in Singapore
Critical Role of Reactive Oxygen Species and Mitochondrial Permeability Transition in Microcystin‐Induced Rapid Apoptosis in Rat Hepatocytes
It is concluded that the M‐LR–induced ROS formation leads to the onset of MPT and apoptosis, and a specific MPT inhibitor, cyclosporin A (CsA), prevented the increase of ROS production, delayed the onsetof MPT, and, subsequently, cell death.
Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.
- Siyuan Zhang, Y. Won, C. Ong, Han-Ming Shen
- Biology, ChemistryCurrent Medicinal Chemistry - Anti-Cancer Agents
- 1 May 2005
Many SLs are emerging as promising anti-cancer agents with potential applications in both cancer chemotherapy and chemoprevention, and the structure-activity relationship of SLs is discussed, along with the molecular mechanisms involved.
CRITICAL ROLE OF REACTIVE OXYGEN SPECIES FORMATION IN MICROCYSTIN-INDUCED CYTOSKELETON DISRUPTION IN PRIMARY CULTURED HEPATOCYTES
- W. Ding, Han-Ming Shen, C. Ong
- Biology, ChemistryJournal of Toxicology and Environmental Health…
- 23 November 2001
The results indicate that M-LR initiated reactive oxygen species (ROS) formation followed by altering the cytoskeleton structures, which eventually led to significant LDH leakage, which provides further evidence that ROS formation, especially superoxide radical, plays a crucial role in M- LR-induced disruption of cytos skeleton organization and consequent hepatotoxicity.
Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes.
Investigation of the effects of microcystic cyanobacteria extract collected from a contaminated water source on the organization of cellular microtubules and microfilaments in hepatocytes suggests that intracellular GSH plays an important role in MCE-induced cytotoxicity and cytoskeleton changes in primary cultured rat hepatocytes.