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Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results
The combined clinimetric results of this study support the validity of the MDS‐UPDRS for rating PD. Expand
Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force
  • B. Dubois, D. Burn, +18 authors M. Emre
  • Psychology, Medicine
  • Movement disorders : official journal of the…
  • 15 December 2007
The main focus of this article is to operationalize the diagnosis of PD‐D and to propose pratical guidelines based on a two level process depending upon the clinical scenario and the expertise of the evaluator involved in the assessment. Expand
Variable expression of Parkinson's disease
Among the patients participating in the DATATOP, older age at onset with bradykinesia, or with the PIGD form of PD, is associated with more functional disability than when the symptoms are dominated by tremor or begin at a younger age. Expand
MDS research criteria for prodromal Parkinson's disease
These criteria represent a first step in the formal delineation of early stages of PD and will require constant updating as more information becomes available. Expand
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease.
Deprenyl but not tocopherol delays the onset of disability associated with early, otherwise untreated Parkinson's disease and the action of deprenyl that accounts for its beneficial effects remains unclear. Expand
Oxidative stress and the pathogenesis of Parkinson's disease
Selegiline may act through a mechanism unrelated to MAO-B to increase neurotrophic factor activity and upregulate molecules such as glutathione, SOD, catalase, and BCL-2 protein, which protect against oxidant stress and apoptosis. Expand
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.
Bilateral stimulation of the subthalamic nucleus or pars interna of the globus pallidus is associated with significant improvement in motor function in patients with Parkinson's disease whose condition cannot be further improved with medical therapy. Expand
A radical hypothesis for neurodegeneration
  • C. Olanow
  • Medicine
  • Trends in Neurosciences
  • 1 November 1993
Point mutations in the cytosolic Cu/Zn superoxide dismutase (SOD-1) gene have been detected in association with familial amyotrophic lateral sclerosis, consistent with the hypothesis that free radicals contribute to the pathogenesis of FALS and possibly to the Pathogenesis of other neurodegenerative disorders such as Parkinson's disease. Expand
DLB and PDD boundary issues
The authors agreed to endorse “Lewy body disorders” as the umbrella term for PD, PDD, and DLB to promote the continued practical use of these three clinical terms, and to encourage efforts at drug discovery that target the mechanisms of neurodegeneration shared by these disorders of α-synuclein metabolism. Expand