C. Ofria

Publications
Influence

Evolution of digital organisms at high mutation rates leads to survival of the flattest

Claus O. Wilke, Jia Lan Wang, C. Ofria, Richard E. Lenski, C. Adami
Biology, Medicine
Nature
19 July 2001

Darwinian evolution favours genotypes with high replication rates, a process called ‘survival of the fittest’. However, knowing the replication rate of each individual genotype may not suffice to… Expand

The evolutionary origin of complex features

Richard E. Lenski, C. Ofria, R. Pennock, C. Adami
Biology, Medicine
Nature
8 May 2003

A long-standing challenge to evolutionary theory has been whether it can explain the origin of complex organismal features. We examined this issue using digital organisms—computer programs that… Expand

Avida: A Software Platform for Research in Computational Evolutionary Biology

C. Ofria, C. Wilke
Computer Science, Medicine
Artificial Life
1 April 2004

Avida is a software platform for experiments with self-replicating and evolving computer programs. Expand

PERSPECTIVE:EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS

J. D. de Visser, J. Hermisson, +16 authors M. Whitlock
Biology, Medicine
Evolution; international journal of organic…
1 September 2003

Abstract Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein… Expand

Evolution of Biological Complexity

C. Adami, C. Ofria, T. Collier
Biology, Medicine
Proc. Natl. Acad. Sci. USA
25 April 2000

We show that, because natural selection forces genomes to behave as a natural "Maxwell Demon," within a fixed environment, genomic complexity is forced to increase. Expand

Distributed Cooperative Caching in Social Wireless Networks

M. Taghizadeh, Kristopher K. Micinski, S. Biswas, C. Ofria, Eric Torng
Computer Science
IEEE Transactions on Mobile Computing
1 June 2013

This paper introduces cooperative caching policies for minimizing electronic content provisioning cost in Social Wireless Networks (SWNET) with homogenous and heterogeneous object demands. Expand

Evolving coordinated quadruped gaits with the HyperNEAT generative encoding

J. Clune, Benjamin E. Beckmann, C. Ofria, R. Pennock
Computer Science
IEEE Congress on Evolutionary Computation
18 May 2009

This paper demonstrates that HyperNEAT, a new and promising generative encoding for evolving neural networks, can evolve quadruped gaits without an engineer manually decomposing the problem. Expand

On the Performance of Indirect Encoding Across the Continuum of Regularity

J. Clune, K. Stanley, R. Pennock, C. Ofria
Mathematics, Computer Science
IEEE Transactions on Evolutionary Computation
1 June 2011

This paper investigates how an evolutionary algorithm with an indirect encoding exploits the property of phenotypic regularity, an important design principle found in natural organisms and engineered designs. Expand

Genome complexity, robustness and genetic interactions in digital organisms

R. Lenski, C. Ofria, T. Collier, C. Adami
Biology, Medicine
Nature
12 August 1999

Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the… Expand

Balancing Robustness and Evolvability

R. Lenski, J. Barrick, C. Ofria
Biology, Medicine
PLoS biology
1 December 2006

Can a single unifying mathematical framework help to explain robustness - the ability of organisms to persist in the face of changing conditions - at all biological scales, from biochemical to… Expand

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