C. O'connor

Publications1,224
h-index134
Citations67,260
Highly Influential Citations1,871
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Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.
CONTEXT Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects… Expand
  • 1,442
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Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry.
OBJECTIVES We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF). BACKGROUND Heart failure with preserved… Expand
  • 888
  • 46
Sertraline Treatment of Major Depression in Patients With Acute MI or Unstable Angina
Results Sertraline had no significant effect on mean (SD) LVEF (sertraline: baseline, 54% [10%]; week 16, 54% [11%]; placebo: baseline, 52% [13%]; week 16, 53% [13%]), treatment-emergent increase in… Expand
  • 963
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Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure.
OBJECTIVES The goal of this study was to determine the prevalence of worsening renal function (WRF) among hospitalized heart failure (HF) patients, clinical predictors of WRF, and hospital outcomes… Expand
  • 795
  • 28
Diuretic strategies in patients with acute decompensated heart failure.
BACKGROUND Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use. METHODS In a prospective,… Expand
  • 775
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Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.
IMPORTANCE Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved… Expand
  • 802
  • 27
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Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure.
BACKGROUND Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes. OBJECTIVE To determine the prevalence and… Expand
  • 882
  • 26
  • PDF
Depression, Heart Rate Variability, and Acute Myocardial Infarction
Background—Clinical depression is associated with an increased risk for mortality in patients with a recent myocardial infarction (MI). Reduced heart rate variability (HRV) has been suggested as a… Expand
  • 736
  • 26
  • PDF
Coronary bypass surgery with or without surgical ventricular reconstruction.
BACKGROUND Surgical ventricular reconstruction is a specific procedure designed to reduce left ventricular volume in patients with heart failure caused by coronary artery disease. We conducted a… Expand
  • 574
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A standardized definition of ischemic cardiomyopathy for use in clinical research.
OBJECTIVES We sought to evaluate the association between the extent of coronary artery disease (CAD) and survival in patients with symptomatic heart failure (HF) and to create the most prognostically… Expand
  • 469
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