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Comparative analysis of visual outcomes with 4 intraocular lenses: Monofocal, multifocal, and extended range of vision.
TLDR
Comparing the visual acuity, refractive outcomes, and quality of vision in patients with bilateral implantation of 4 intraocular lenses found the extended-range-of-vision IOL provided significantly better intermediate visual restoration after cataract surgery than the monofocal Iol and +3.0 D multifocal IOL, with significantly betterquality of vision. Expand
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
TLDR
The original observation that retinal ischemia-reperfusion reduces endogenous AEA via enhanced expression of FAAH supports the deduction that this is implicated in retinal cell loss caused by high IOP in the RGC layer. Expand
Direct costs of glaucoma and severity of the disease: a multinational long term study of resource utilisation in Europe
TLDR
It is demonstrated for the first time in Europe that resource utilisation and direct medical costs of glaucoma management increase with worsening disease severity. Expand
Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo
TLDR
Results provide original evidence for calpain-mediated cleavage of Beclin-1 and deregulation of basal autophagy in the rat retina that has undergone ocular ischemia/reperfusion injury and suggest a pro-survival role of the autophagic process in this neuronal cell type. Expand
Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects.
TLDR
The prevalence of primary open-angle glaucoma (POAG) has been increasing, and this trend is undoubtedly due at least in part to advances in diagnostic technology. Expand
Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
TLDR
The hypothesis that oxidative stress and the decrease of antioxidant defenses are associated with the progression of diabetic retinopathy to its proliferative form is supported. Expand
Retinal damage caused by high intraocular pressure-induced transient ischemia is prevented by coenzyme Q10 in rat.
TLDR
It is shown that synaptic glutamate increases at 130min from beginning of reperfusion and delayed apoptosis in the RGC layer is seen at 24h, suggesting that oxidative stress and energy failure might be implicated in the mechanisms of RGC death. Expand
Glaucoma and Alzheimer Disease: One Age-Related Neurodegenerative Disease of the Brain
TLDR
Preclinical and clinical evidence gathered so far support the notion that glaucoma is a widespread neurodegenerative condition whose common pathogenetic mechanisms with other diseases, i.e. Alzheimer Disease, should be further investigated as they may shed new light on these diseases improving both diagnosis and treatments. Expand
Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat.
TLDR
The data suggest that acute elevation of IOP increases intraretinal levels of glutamate with consequent abnormal activation of NMDA and non-NMDA subtypes of glutamate receptors and increased NOS activity leading to excitotoxic, glutamate-mediated, RGC death. Expand
Prevalence of blindness and low vision in an Italian population: a comparison with other European studies
TLDR
Age-specific prevalence rates in Ponza are fairly consistent with those for other European countries with similar socio-economic conditions and public healthcare systems, but a substantial percentage of visual losses remains uncorrected despite the availability of potentially curative therapy. Expand
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