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Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms. Prior studies have shown that the transcription factor… Expand
Regulation of Cell-Surface Genes and Biofilm Formation by the C. albicans Transcription Factor Bcr1p
The impact of many microorganisms on their environment depends upon their ability to form surface bound communities called biofilms . Biofilm formation on implanted medical devices has severe… Expand
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, we… Expand
Biofilm Matrix Regulation by Candida albicans Zap1
The zinc-responsive transcription factor Zap1 has a striking role in fungal biofilm formation and is reported to regulate matrix formation.
Complementary Adhesin Function in C. albicans Biofilm Formation
BACKGROUND Biofilms are surface-associated microbial communities with significant environmental and medical impact. Here, we focus on an adherence mechanism that permits biofilm formation by Candida… Expand
Control of the C. albicans Cell Wall Damage Response by Transcriptional Regulator Cas5
- V. Bruno, S. Kalachikov, R. Subaran, C. Nobile, C. Kyratsous, A. Mitchell
- Biology, Medicine
- PLoS pathogens
- 1 March 2006
The fungal cell wall is vital for growth, development, and interaction of cells with their environment. The response to cell wall damage is well understood from studies in the budding yeast… Expand
Mucosal Tissue Invasion by Candida albicans Is Associated with E-Cadherin Degradation, Mediated by Transcription Factor Rim101p and Protease Sap5p
- C. C. Villar, H. Kashleva, C. Nobile, A. Mitchell, A. Dongari-Bagtzoglou
- Biology, Medicine
- Infection and Immunity
- 5 March 2007
ABSTRACT The ability of Candida albicans to invade mucosal tissues is a major virulence determinant of this organism; however, the mechanism of invasion is not understood in detail. Proteolytic… Expand
Candida albicans Biofilms and Human Disease.
In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host cells. Candida albicans is the most prevalent fungal species of the human microbiota; this species… Expand
Function of Candida albicans Adhesin Hwp1 in Biofilm Formation
ABSTRACT Hwp1 is a well-characterized Candida albicans cell surface protein, expressed only on hyphae, that mediates tight binding to oral epithelial cells. Prior studies indicate that HWP1… Expand
Candida albicans biofilms: development, regulation, and molecular mechanisms.
A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional… Expand