• Publications
  • Influence
Experience with a once-daily aminoglycoside program administered to 2,184 adult patients.
Once-daily aminoglycoside (ODA) regimens have been instituted to maximize bacterial killing by optimizing the peak concentration/MIC ratio and to reduce the potential for toxicity. We initiated anExpand
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Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, withExpand
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Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia.
A prospective, randomized pilot study was undertaken to compare the efficacy of continuous versus intermittent ceftazidime in ICU patients with nosocomial pneumonia. Ceftazidime was administeredExpand
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The pharmacodynamics of aminoglycosides.
Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidalExpand
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Population Pharmacokinetic Analysis and Dosing Regimen Optimization of Meropenem in Adult Patients
The objectives of this study were to develop a meropenem population pharmacokinetic model using patient data and use it to explore alternative dosage regimens that could optimize the currently usedExpand
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Impact of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species on clinical outcomes and hospital costs: a matched cohort study.
OBJECTIVES To evaluate the economic and clinical impact of infection with extended-spectrum beta -lactamase (ESBL)-producing Escherichia coli and Klebsiella species (ESBL-EK). DESIGN AExpand
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Pharmacokinetics and pharmacodynamics of newer macrolides.
  • C. Nightingale
  • Medicine
  • The Pediatric infectious disease journal
  • 1 April 1997
Requirements for the antimicrobial activity of an antibiotic are: (1) binding of the drug to a specific site in the bacteria; (2) occupation of a critical number of binding sites; and (3) persistenceExpand
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Does the use of antibiotics in food animals pose a risk to human health? A reply to critics
University of London, London, UK; Cox Associates, Denver, CO; Kansas State University, Manhattan, KS, and Livestock Information Services, Callaway, NE; JMI Laboratories, North Liberty, IA; HartfordExpand
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Adherence to highly active antiretroviral therapy predicts virologic outcome at an inner-city human immunodeficiency virus clinic.
This study's hypothesis is that human immunodeficiency virus-infected patients in the inner city (predominantly injection drug users and ethnic minorities) do not take highly active antiretroviralExpand
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Clinical efficacy and pharmacoeconomics of a continuous-infusion piperacillin-tazobactam program in a large community teaching hospital.
STUDY OBJECTIVE To compare continuous versus intermittent administration of piperacillin-tazobactam with regard to clinical, microbiologic, and economic outcomes. DESIGN Prospective, open-labelExpand
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