[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.
Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis
- F. Awouters, C. Niemegeers, F. Lenaerts, P. Janssen
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 1 September 1978
It is concluded that delay of castor oil‐induced diarrhoea in rats allows a detailed characterization of aspirin‐like compounds, and that inhibition of prostaglandin biosynthesis is insufficient to suppress the intestinal effects of the oil.
The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.
Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discrimination
Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments
Theoretical and methodological considerations on drug discrimination learning
The method is found to yield clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects and the experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects.
Rapid desensitization and down-regulation of 5-HT2 receptors by DOM treatment.
Survey on the pharmacodynamics of the new antipsychotic risperidone
Risperidone can be characterized as a potent D2 antagonist with predominant 5HT2 antagonistic activity and optimal pharmacokinetic properties.
Etomidate, a potent non-barbiturate hypnotic. Intravenous etomidate in mice, rats, guinea-pigs, rabbits and dogs.
- P. Janssen, C. Niemegeers, R. Marsboom
- Medicine, BiologyArchives internationales de pharmacodynamie et de…
- 1 March 1975
The hypnotic effects of etomidate at very low dose levels in different laboratory animals are compared with the effects obtained in human subjects, in which successful induction of anaesthesia was obtained without producing any release of histamine and with only minimal effects on cardiovascular and respiratory functions.
A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist.