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Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis
It is concluded that delay of castor oil‐induced diarrhoea in rats allows a detailed characterization of aspirin‐like compounds, and that inhibition of prostaglandin biosynthesis is insufficient to suppress the intestinal effects of the oil. Expand
Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments
It is suggested that stimulus generalization with cocaine may be contingent upon increasing the functional availability of endogenous dopamine and, perhaps, of norepinephrine irrespective of the presynaptic mechanism from which such increase may result and that differential stimulus generalized of drugs with cocaine (in terms of dose, subjects, slope, and rate effects) may parallel their differential primary reinforcing properties. Expand
Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discrimination
It is concluded that the training dose of a narcotic agonist contributes critically in determining the acquisition of discriminative response control as well as various quantitative and qualitative aspects of stimulus generalization with the training drug condition. Expand
Theoretical and methodological considerations on drug discrimination learning
The method is found to yield clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects and the experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects. Expand
Serotonergic component of neuroleptic receptors
It is suggested that serotonergic, as well as dopamine agonists or antagonists for rat frontal cortex and striatal receptors are involved in the mechanism of action of neuroleptic drugs. Expand
Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs.
Sufentanil (R 30 730), N-[4-methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide, is a chemically novel, highly potent and extremely safe intravenous morphine-like agent inExpand
Survey on the pharmacodynamics of the new antipsychotic risperidone
Risperidone can be characterized as a potent D2 antagonist with predominant 5HT2 antagonistic activity and optimal pharmacokinetic properties. Expand
Etomidate, a potent non-barbiturate hypnotic. Intravenous etomidate in mice, rats, guinea-pigs, rabbits and dogs.
The hypnotic effects of etomidate at very low dose levels in different laboratory animals are compared with the effects obtained in human subjects, in which successful induction of anaesthesia was obtained without producing any release of histamine and with only minimal effects on cardiovascular and respiratory functions. Expand