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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, aExpand
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The complex world of WNT receptor signalling
  • C. Niehrs
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 December 2012
30 years after the identification of WNTs, their signal transduction has become increasingly complex, with the discovery of more than 15 receptors and co-receptors in seven protein families. TheExpand
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LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Wnt glycoproteins have been implicated in diverse processes during embryonic patterning in metazoa. They signal through frizzled-type seven-transmembrane-domain receptors to stabilize β-catenin. WntExpand
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Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
Multiple signaling pathways, including Wnt signaling, participate in animal development, stem cell biology, and human cancer. Although many components of the Wnt pathway have been identified,Expand
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Function and biological roles of the Dickkopf family of Wnt modulators
  • C. Niehrs
  • Medicine, Biology
  • Oncogene
  • 4 December 2006
Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted proteins that typicallyExpand
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Antagonizing the Spemann organizer: role of the homeobox gene Xvent‐1.
We have identified a novel homeobox gene, Xvent‐1, that is differentially expressed in the ventral marginal zone of the early Xenopus gastrula. Evidence is presented from mRNA microinjectionExpand
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A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus.
Anteroposterior (AP) patterning of the vertebrate neural plate is initiated during gastrulation and is regulated by Spemann's organizer and its derivatives. The prevailing model for AP patterningExpand
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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
The Wnt family of secreted glycoproteins mediate cell cell interactions during cell growth and differentiation in both embryos and adults. Canonical Wnt signalling by way of the beta-catenin pathwayExpand
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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.
Signalling by Wnt proteins (Wingless in Drosophila) has diverse roles during embryonic development and in adults, and is implicated in human diseases, including cancer. LDL-receptor-related proteinsExpand
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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show that Dkk1 null mutantExpand
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