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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].
TLDR
ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer. Expand
Differential roles for the coactivators CBP and p300 on TCF/β-catenin-mediated survivin gene expression
TLDR
It is demonstrated that CBP and p300 play very distinct roles in survivin gene transcription, the crucial coactivator for TCF/β-catenin-mediated survivin transcription. Expand
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
TLDR
It is demonstrated that IQ-1, by targeting the PR72/130 subunit of the serine/threonine phosphatase PP2A, prevents β-catenin from switching coactivator usage from CBP to p300 and is critical for the maintenance of murine stem cell pluripotency. Expand
Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response
TLDR
TGF-β induction of α-smooth muscle actin (α-SMA) involves ternary complex formation among Smad3, β-catenin, and CBP, which suggests a new therapeutic approach to pulmonary fibrosis by specifically uncoupling CBP/ catenin-dependent signaling downstream of TGF- β. Expand
Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.
TLDR
This work is the first to show that EphB4 is preferentially induced in colorectal cancer, in contrast to EphEphB2, whereby tumor cells acquire a survival advantage. Expand
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.
TLDR
It is proposed that increased T cell factor/beta-catenin/CBP-mediated transcription, as well as a failure to switch to TCF/ beta-catanin/p300- mediated transcription, play an important role in decreasing neuronal differentiation. Expand
A small molecule inhibitor of -cateninCREB-binding protein transcription
TLDR
To identify small molecule antagonists of this pathway, transformed colorectal cells were challenged with a sec-ondary structure-templated chemical library, looking for com-pounds that inhibit -catenin-responsive genes. Expand
Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
TLDR
It is reported here that ICG-001 significantly inhibits β-catenin signaling and attenuates bleomycin-induced lung fibrosis in mice, while concurrently preserving the epithelium. Expand
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
TLDR
ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer. Expand
Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia
TLDR
It is reported that selective disruption of the CBP/β- and γ-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and loss of self-renewal capacity. Expand
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