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SF3B1 mutations constitute a novel therapeutic target in breast cancer
Mutations in genes encoding proteins involved in RNA splicing have been found to occur at relatively high frequencies in several tumour types including myelodysplastic syndromes, chronic lymphocyticExpand
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Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast
Micropapillary carcinoma (MPC) is a rare histological special type of breast cancer, characterized by an aggressive clinical behaviour and a pattern of copy number aberrations (CNAs) distinct fromExpand
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Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast
Neuroendocrine breast carcinomas represent a rare subtype of breast cancer. Their definition, prevalence, and prognosis remain controversial in the literature. The 2012 WHO classification of breastExpand
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Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes
The application of paired‐end next generation sequencing approaches has made it possible to systematically characterize rearrangements of the cancer genome to base‐pair level. Utilizing thisExpand
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MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene
Breast adenoid cystic carcinoma (AdCC), a rare type of triple‐negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB–NFIB fusion gene.Expand
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Breast cancer intratumor genetic heterogeneity: causes and implications
There is burgeoning evidence to suggest that tumor evolution follows the laws of Darwinian evolution, whereby individual tumor cell clones harbor private genetic aberrations in addition to theExpand
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Bi‐allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer
Homologous recombination (HR) DNA repair‐deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers,Expand
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HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models1
BACKGROUND: HMGA1 is a non-histone nuclear protein that regulates cellular proliferation, invasion and apoptosis and is overexpressed in many carcinomas. In this study we sought to explore theExpand
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APSiC: Analysis of Perturbation Screens for the Identification of Novel Cancer Genes
Systematic perturbation screens provided comprehensive resources for the elucidation of cancer driver genes. However, few algorithms have been developed to robustly interrogate such datasets,Expand