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Genome sequence of the human malaria parasite Plasmodium falciparum
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genomeExpand
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REAPR: a universal tool for genome assembly evaluation
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked. Here we present REAPR, a toolExpand
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Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes
Summary A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host redExpand
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Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
Plasmodium falciparum expresses on the host erythrocyte surface clonally variant antigens and ligands that mediate adherence to endothelial receptors. Both are central to pathogenesis, since theyExpand
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ABACAS: algorithm-based automatic contiguation of assembled sequences
ABACAS is a stand alone program intended to rapidly contiguate (align, order, orientate), visualize and design primers to close gaps on shotgun assembled contigs based on a reference sequence. Expand
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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisininExpand
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Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of varExpand
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Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum.
Many pathogens evade the host immune response or adapt to their environment by expressing surface proteins that undergo rapid switching. In the case of Plasmodium falciparum, products of a multigeneExpand
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New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
Recent advances in high‐throughput sequencing present a new opportunity to deeply probe an organism's transcriptome. In this study, we used Illumina‐based massively parallel sequencing to gain newExpand
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A comprehensive evaluation of assembly scaffolding tools
BackgroundGenome assembly is typically a two-stage process: contig assembly followed by the use of paired sequencing reads to join contigs into scaffolds. Scaffolds are usually the focus of reportedExpand
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