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Novel Lyssavirus in Bat, Spain
TLDR
A new tentative lyssavirus was found in a bent-winged bat (Miniopterus schreibersii) in Spain, and it seems to be more closely related to the West Causasian bat virus, and especially to the Ikoma lySSavirus.
Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis
TLDR
The network analysis suggests that the tyrosine kinase EphB4 has high selectivity potential, which is consistent with the selectivity profile of two novel EphP4 inhibitors, and systematic guidelines are proposed to develop selective inhibitors.
The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
TLDR
X-ray crystal structures of three different bromodomains in complex with acetyl indole derivatives reveal the influence of the gatekeeper residue on the orientation of small-molecule ligands in the acetyl lysine binding site.
In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control
TLDR
Endoxifen is established as potent and reproducible complementary compound to 4-OHT to control ERT2 domain fusion proteins in vivo, and provide a framework for efficient chemically controlled recombination experiments.
Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds.
TLDR
A silver-catalyzed radical cascade process involving the sequential formation of two new C-C bonds and one C-N bond, a formal 1,4-aryl migration, and desulfonylation of the starting material explains the regioselective formation of densely functionalized heterocycles in a straightforward manner.
Gold-catalyzed ethynylation of arenes.
  • T. de Haro, C. Nevado
  • Chemistry, Biology
    Journal of the American Chemical Society
  • 20 January 2010
TLDR
A novel gold-catalyzed ethynylation of aromatic rings with electron-deficient alkynes via gold catalyzed C-H activation of both C(sp)-H and C( sp(2))-H bonds has been developed, highlighting the synthetic potential of gold chemistry.
Flexible gold-catalyzed regioselective oxidative difunctionalization of unactivated alkenes.
TLDR
The research group has recently combined the unique carbophilicity of gold complexes with the Au/Au redox catalytic cycles to design new transformations, envisioned that highly oxidized gold(III) intermediates generated in the presence of oxidants such as Selectfluor or PhI(OAc)2 could trigger the selective oxidative difunctionalization of alkenes.
Intramolecular reactions of alkynes with furans and electron rich arenes catalyzed by PtCl2: the role of platinum carbenes as intermediates.
TLDR
On the basis of DFT calculations, a cyclopropyl platinacarbene complex was found as the key intermediate in the process, and dicarbonyl compounds are obtained, which support the proposed mechanism.
Palladium‐Catalyzed Incorporation of Atmospheric CO2: Efficient Synthesis of Functionalized Oxazolidinones.
Methods to incorporate atmospheric CO2 into organic molecules are on demand. Here we present two Pdcatalyzedmulticomponent reactions that provide functionalized oxazolidinones from propargylamines,
Transition Metal Catalyzed Hydroarylation of Alkynes
SYNTHESIS 2005, No. 2, pp 0167–0182xx.xx.2005 Advanced online publication: 13.01.2005 DOI: 10.1055/s-2005-861781; Art ID: E11904SS © Georg Thieme Verlag Stuttgart · New York Abstract: The different
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