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Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis
The network analysis reveals the likelihood to find selective inhibitors targeting the ATP binding site. Expand
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The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
Small-molecule hits for the bromodomains of CREBBP and BAZ2B have been identified by scaffold hopping followed by docking of a set of ∼200 compounds containing the acetyl indole scaffold. ChemicalExpand
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In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control
Mutant Estrogen Receptor (ERT2) ligand-binding domain fusions with Cre recombinase are a key tool for spatio-temporally controlled genetic recombination with the Cre/lox system. CreERT2 isExpand
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Gold-catalyzed ethynylation of arenes.
A novel gold-catalyzed ethynylation of aromatic rings with electron-deficient alkynes via gold catalyzed C-H activation of both C(sp)-H and C(sp(2))-H bonds has been developed. This transformationExpand
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Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds.
The addition of a variety of radicals to the double bond of N-(arylsulfonyl)acrylamides can trigger cyclization/aryl migration/desulfonylation cascades via amidyl radical intermediates 2. Herein, weExpand
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Flexible gold-catalyzed regioselective oxidative difunctionalization of unactivated alkenes.
Diols, diamines, and aminoalcohols are ubiquitous functionalities in complex organic molecules. From the seminal work of Sharpless and co-workers on the intermolecular osmiumcatalyzed asymmetricExpand
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Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).
The tyrosine kinase EphB4 is an attractive target for drug design because of its recognized role in cancer-related angiogenesis. Recently, a series of commercially available xanthine derivatives wereExpand
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Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.
We have discovered a novel chemical class of inhibitors of the EphB4 tyrosine kinase by fragment-based high-throughput docking followed by explicit solvent molecular dynamics simulations forExpand
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Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
The quest for selective C–H functionalization reactions, able to provide new strategic opportunities for the rapid assembly of molecular complexity, represents a major focus of the chemicalExpand
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Cationic gold(I) complexes: highly alkynophilic catalysts for the exo- and endo-cyclization of enynes.
Alkynophilic cationic gold(I) complexes are very active catalysts for reactions of enynes that proceed exclusively through cyclopropyl carbene complexes as intermediates (see scheme). With suchExpand
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