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Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
Autoinhibition is a recurring mode of protein kinase regulation and can be based on diverse molecular mechanisms. Here, we show by crystal structure analysis, nuclear magnetic resonance (NMR)‐based… Expand
Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Human mitogen-activated protein kinases (MAPK)-interacting kinases 1 and 2 (Mnk1 and Mnk2) target the translational machinery by phosphorylation of the eukaryotic initiation factor 4E (eIF4E). Here,… Expand
Determination of artemether and its metabolite, dihydroartemisinin, in plasma by high-performance liquid chromatography and electrochemical detection in the reductive mode.
- N. Sandrenan, A. Sioufi, J. Godbillon, C. Netter, M. Donker, C. van Valkenburg
- Chemistry, Medicine
- Journal of chromatography. B, Biomedical sciences…
- 28 March 1997
An analytical method for the determination of artemether (A) and its metabolite dihydroartemisinin (DHA) in human plasma has been developed and validated. The method is based on high-performance… Expand
Interactions of a Family 18 Chitinase with the Designed Inhibitor HM508 and Its Degradation Product, Chitobiono-δ-lactone*
- G. Vaaje-Kolstad, A. Vasella, +6 authors D. V. van Aalten
- Medicine, Chemistry
- Journal of Biological Chemistry
- 30 January 2004
We describe enzymological and structural analyses of the interaction between the family 18 chitinase ChiB from Serratia marcescens and the designed inhibitor… Expand
Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.
RNA recognition motifs (RRMs) constitute versatile macromolecular interaction platforms. They are found in many components of spliceosomes, in which they mediate RNA and protein interactions by… Expand
Tailor made activation segment for autoinhibition
General acid catalysis is a powerful and widely used strategy in enzymatic nucleophilic displacement reactions. For example, hydrolysis/ phosphorolysis of the N-glycosidic bond in nucleosides and… Expand
Structural analyses of spliceosomal proteins: the Prp19-complex and the U11/U12 65K protein.
- C. Netter
C-terminal RNA Recognition Motif of the U11/U12 65K Protein
Structures of Mnk-2 reveal novel aspects of kinase regulation