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Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
Autoinhibition is a recurring mode of protein kinase regulation and can be based on diverse molecular mechanisms. Here, we show by crystal structure analysis, nuclear magnetic resonance (NMR)‐basedExpand
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Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Human mitogen-activated protein kinases (MAPK)-interacting kinases 1 and 2 (Mnk1 and Mnk2) target the translational machinery by phosphorylation of the eukaryotic initiation factor 4E (eIF4E). Here,Expand
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Determination of artemether and its metabolite, dihydroartemisinin, in plasma by high-performance liquid chromatography and electrochemical detection in the reductive mode.
An analytical method for the determination of artemether (A) and its metabolite dihydroartemisinin (DHA) in human plasma has been developed and validated. The method is based on high-performanceExpand
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Interactions of a Family 18 Chitinase with the Designed Inhibitor HM508 and Its Degradation Product, Chitobiono-δ-lactone*
We describe enzymological and structural analyses of the interaction between the family 18 chitinase ChiB from Serratia marcescens and the designed inhibitorExpand
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Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.
RNA recognition motifs (RRMs) constitute versatile macromolecular interaction platforms. They are found in many components of spliceosomes, in which they mediate RNA and protein interactions byExpand
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Tailor made activation segment for autoinhibition
General acid catalysis is a powerful and widely used strategy in enzymatic nucleophilic displacement reactions. For example, hydrolysis/ phosphorolysis of the N-glycosidic bond in nucleosides andExpand
Structure of human Mnk2 Kinase Domain