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Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
It is found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in the FK506 binding protein 5 gene increased the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma–dependent DNA demethylation in functional glucocorticoid response elements of FKBP5. Expand
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
There were no main effects of the SNPs on PTSD symptoms and no significant genetic interactions with level of non-child abuse trauma as predictor of adult PTSD symptoms, suggesting a potential gene-childhood environment interaction for adult PTSD. Expand
The link between childhood trauma and depression: Insights from HPA axis studies in humans
- C. Heim, D. Newport, T. Mletzko, Andrew H Miller, C. Nemeroff
- Medicine, Psychology
- 1 July 2008
Results from a series of clinical studies suggesting that childhood trauma in humans is associated with sensitization of the neuroendocrine stress response, glucocorticoid resistance, increased central corticotropin-releasing factor activity, immune activation, and reduced hippocampal volume are summarized, indicating the existence of biologically distinguishable subtypes of depression as a function of childhood trauma. Expand
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
Preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness. Expand
Depression, desperation, and suicidal ideation in college students: results from the American Foundation for Suicide Prevention College Screening Project at Emory University
- S. Garlow, Jill Rosenberg, +4 authors C. Nemeroff
- Psychology, Medicine
- Depression and anxiety
- 1 June 2008
There is a strong relationship between severity of depressive symptoms and suicidal ideation in college students, and this underscores the need to provide effective mental health outreach and treatment services to this vulnerable population. Expand
A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression.
- M. Keller, J. P. Mccullough, +9 authors J. Zajecka
- The New England journal of medicine
- 18 May 2000
Although about half of patients with chronic forms of major depression have a response to short-term treatment with either nefazodone or a cognitive behavioral-analysis system of psychotherapy, the combination of the two is significantly more efficacious than either treatment alone. Expand
The role of dopamine in the pathophysiology of depression.
Several studies support the hypothesis that major depression is associated with a state of reduced DA transmission, possibly reflected bycompensatory up-regulation of D2receptors, and further research on the contribution of DA to the pathophysiology of depression is justified to improve outcomes for patients with treatment-resistant and nonremitting depression. Expand
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
- M. Owens, W. N. Morgan, S. Plott, C. Nemeroff
- Biology, Medicine
- The Journal of pharmacology and experimental…
- 1 December 1997
Novel findings, not widely described previously, suggest that many of the individual drugs studied in these experiments possess some structural characteristic that determines affinity for several G protein-coupled, but not muscarinic, receptors. Expand
The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment.
Treatment of depression in patients with CVD improves their dysphoria and other signs and symptoms of depression, improves quality of life, and perhaps even increases longevity. Expand
The role of corticotropin-releasing factor in depression and anxiety disorders.
The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported. Expand