• Publications
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Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
  • L. Sun, P. Goodman, +12 authors F. Uckun
  • Biology, Medicine
  • Journal of clinical oncology : official journal…
  • 1 December 1999
PURPOSE We sought to determine if molecular abnormalities involving the Ikaros gene could contribute to the development of acute lymphoblastic leukemia (ALL) in children. PATIENTS AND METHODS WeExpand
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Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
  • L. Sun, N. Heerema, +6 authors F. Uckun
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 January 1999
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice that express only non-DNA binding dominant-negative "leukemogenic" IkarosExpand
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  • Open Access
Molecular Correlates of Primate Nuclear Transfer Failures
Somatic cell nuclear transfer (SCNT) ([1][1]) in nonhuman primates could accelerate medical research by contributing identical animals for research and clarifying embryonic stem cell potentialsExpand
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Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction.
Therapeutic cloning or nuclear transfer for stem cells (NTSC) seeks to overcome immune rejection through the development of embryonic stem cells (ES cells) derived from cloned blastocysts. TheExpand
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Culture of human embryonic stem cells
The successful culture and maintenance of human embryonic stem cells (HESCs) offers great promise for furthering our basic understanding of many regulatory and developmental processes, and forExpand
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The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility
Successful fertilization in humans, achieved when parental chromosomes intermix at first mitosis, requires centrosome restoration and microtubule-mediated motility. Imaging of inseminated humanExpand
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Cell cycle adaptations and maintenance of genomic integrity in embryonic stem cells and induced pluripotent stem cells.
Pluripotent stem cells have the capability to undergo unlimited self-renewal and differentiation into all somatic cell types. They have acquired specific adjustments in the cell cycle structure thatExpand
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Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97).
4-(3',5'-Dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97) is a rationally designed potent inhibitor of Janus kinase (JAK)-3. Treatment of mast cells with WHI-P97 inhibited theExpand
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  • Open Access
Expression of TEL-AML1 Fusion Transcripts and Response to Induction Therapy in Standard Risk Acute Lymphoblastic Leukemia
We prospectively examined the frequency of the t(12;21)TEL-AML1 fusion in 504 children with newly diagnosed standard risk ALL using RT-PCR assays. Cells from 95 patients (18.8%) were TEL-AML1+. ThereExpand
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Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
Mast cells play a pivotal role in innate host immune response to gram-negative bacteria. We report that Janus kinase 3 plays a role in mast cell-mediated bacterial clearance and neutrophilExpand
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