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A method for estimating the probability of adverse drug reactions
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance. Expand
Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar).
A shortened 10-item scale for clinical quantitation of the severity of the alcohol withdrawal syndrome has been developed and can be incorporated into the usual clinical care of patients undergoing alcohol withdrawal and into clinical drug trials of alcohol withdrawal. Expand
A validation study of The Geriatric Depression Scale short form
The validity of the Geriatric Depression Scale (GDS) short form was assessed in a geriatric affective disorders outpatient clinic (N = 116). The GDS was highly correlated with the Montgomery AsbergExpand
Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.
Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets. Expand
The role of the brain reward system in depression
A novel approach to study the pathophysiology of MDD is introduced that includes pharmacological probing of BRS pathways together with an elicited and measurable behavioral component (e.g. pleasant effects, increased energy, altered cognition). Expand
Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram
It is concluded that citalopram is neither the source nor the cause of clinically important drug-drug interactions. Expand
Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine.
The results suggest the presence of a hypersensitive response is present in the brain reward system of depressed patients, which may reflect a hypofunctional state and may provide a novel pathophysiologic and therapeutic target for future studies. Expand
Advances in the Diagnosis of Adverse Drug Reactions
The intention is to increase awareness of the different approaches for diagnosing ADRs as well as to stimulate researchers to continue to collect pharmacoepidemiologic information, study the pharmacologic, immunologic, and genetic factors involved in the pathogenesis of drug reactions, and develop and test new diagnostic instruments under various clinical conditions. Expand
Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.
In ethanol-preferring C57BL/6J (C57) mice, decreased dopamine content and turnover in the terminals of the mesolimbic and mesostriatal dopamine neurons, compared with ethanol-avoiding DBA/2J and BALBc mice are demonstrated, suggesting that genetically determined hypodopaminergic function in these pathways plays a role in the predisposition to high voluntary intake of ethanol. Expand
Patterns of benzodiazepine abuse and dependence.
Two groups of subjects emerged: patients who used only benzodiazepines for long periods of time and those who used Benzodiazepine in the context of multiple drug abuse, where Diazepam was most frequently alleged in both groups, but relative preference for other benzodiazines differed. Expand