A method for estimating the probability of adverse drug reactions
- C. Naranjo, U. Busto, D. Greenblatt
- MedicineClinical pharmacology and therapy
- 1 August 1981
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar).
- J. T. Sullivan, K. Sykora, J. Schneiderman, C. Naranjo, E. Sellers
- Medicine, PsychologyBritish Journal of Addiction
- 1 November 1989
A shortened 10-item scale for clinical quantitation of the severity of the alcohol withdrawal syndrome has been developed and can be incorporated into the usual clinical care of patients undergoing alcohol withdrawal and into clinical drug trials of alcohol withdrawal.
A validation study of The Geriatric Depression Scale short form
- N. Herrmann, N. Mittmann, C. Naranjo
- Psychology, Medicine
- 1 May 1996
The Geriatric Depression Scale short form appears to be a useful, valid screening instrument in this population of geriatric affective disorders patients.
Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.
- L. Tremblay, C. Naranjo, U. Busto
- Psychology, BiologyArchives of General Psychiatry
- 1 November 2005
Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets.
The role of the brain reward system in depression
- C. Naranjo, L. Tremblay, U. Busto
- Psychology, BiologyProgress in Neuro-psychopharmacology and…
- 1 May 2001
Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine.
- L. Tremblay, C. Naranjo, L. Cárdenas, N. Herrmann, U. Busto
- Psychology, MedicineArchives of General Psychiatry
- 1 May 2002
The results suggest the presence of a hypersensitive response is present in the brain reward system of depressed patients, which may reflect a hypofunctional state and may provide a novel pathophysiologic and therapeutic target for future studies.
Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram
- K. Brøsen, C. Naranjo
- Medicine, PsychologyEuropean Neuropsychopharmacology
- 1 August 2001
Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.
- S. George, T. Fan, G. Ng, S. Jung, B. O'dowd, C. Naranjo
- BiologyJournal of Pharmacology and Experimental…
- 1 April 1995
In ethanol-preferring C57BL/6J (C57) mice, decreased dopamine content and turnover in the terminals of the mesolimbic and mesostriatal dopamine neurons, compared with ethanol-avoiding DBA/2J and BALBc mice are demonstrated, suggesting that genetically determined hypodopaminergic function in these pathways plays a role in the predisposition to high voluntary intake of ethanol.
Advances in the Diagnosis of Adverse Drug Reactions
- C. Naranjo, N. Shear, K. Lanctôt
- MedicineJournal of clinical pharmacology
- 1 October 1992
The intention is to increase awareness of the different approaches for diagnosing ADRs as well as to stimulate researchers to continue to collect pharmacoepidemiologic information, study the pharmacologic, immunologic, and genetic factors involved in the pathogenesis of drug reactions, and develop and test new diagnostic instruments under various clinical conditions.
Brain reward system activity in major depression and comorbid nicotine dependence.
- L. Cárdenas, L. Tremblay, C. Naranjo, N. Herrmann, M. Zack, U. Busto
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 September 2002
The data show that smoking did not modify the response to d-amph in MDD or control subjects, but decreased overall negative mood state during placebo sessions, which indicates that Severity of depression was significantly correlated with increased rewarding effects of d- amph.
...
...