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Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats.
- S. Nelson, W. Summer, +4 authors J. Andresen
- MedicineThe Journal of infectious diseases
- 1 November 1991
G-CSF augmented the recruitment of PMNL into the lungs of control rats and significantly attenuated the adverse effects of ethanol on PMNL entry into the lung, and enhanced intrapulmonary bactericidal activity against this pathogen in normal and ethanol-treated rats.
Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury
- M. Mahatma, N. Agrawal, E. Dajani, S. Nelson, C. Nakamura, J. Sitton
- MedicineDigestive Diseases and Sciences
- 1 November 1991
It is concluded that misoprostol is a potent inhibitor of TNF systemic production and inhibits the gastric mucosal injury induced by endotoxemia, suggesting a potentially important therapeutic role for misop frostol in inflammatory diseases in which TNF exerts a contributory role.
The effects of ethanol, tumor necrosis factor, and granulocyte colony-stimulating factor on lung antibacterial defenses.
- S. Nelson, G. Bagby, J. Andresen, C. Nakamura, J. Shellito, W. Summer
- MedicineAdvances in experimental medicine and biology
Evidence is emerging indicating that alcohol-abusing hosts are seriously undermined by profound disturbances in cytokine production and activity, and the potential to regulate essential functions of the host defense system which may prevent the development and mitigate the severity of infections in these and other immunocompromised hosts is possessed.
Pyruvate alleviates toxic effects of ethanol on cells in culture
The results suggest that drug cytotoxicity testing in vitro must be done using various types of culture medium, because addition of malate to the medium also reduced the cytotoxic effects.
In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
- S. Sadanobu, M. Watanabe, C. Nakamura, M. Tezuka
- Chemistry, MedicineThe Journal of toxicological sciences
- 20 December 1999
The protective effect of DT827A on a liver injury is due neither to its influence on liver GSH levels nor inhibition of the metabolic activation of CCl4, but a possible mechanism of action for theDT827 series of compounds to indicate an antioxidative effect would be brought about by the role of the compounds as a radical scavenger as well as its reductive effect.
Dharmendra antigen but not integral M. leprae is an efficient inducer of immunostimulant cytokine production by human monocytes, and M. leprae lipids inhibit the cytokine production.
- C. Nakamura, Y. Fukutomi, +4 authors K. Onozaki
- Chemistry, MedicineInternational journal of leprosy and other…
- 1 March 1997
The results suggest that Dh-Ag rather than integral M. leprae may be useful as a vaccine candidate because Dh- Ag is able to induce a large amount of cytokines from monocytes, thus favoring their infection.
Contrasting effects of misoprostol on systemic and intrapulmonary lipopolysaccharide-induced tumor necrosis factor-alpha.
In vivo data show that PGE1 is a potent inhibitor of TNF production by systemic mononuclear phagocytes, and alveolar macrophages appear to be refractory to misoprostol's suppressive effects on LPS-induced TNF.