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Chromosome healing in mouse embryonic stem cells.
The addition of new telomeres to the ends of broken chromosomes, termed chromosome healing, has been extensively studied in unicellular organisms; however, its role in the mammalian cell response toExpand
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  • Open Access
Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse
ABSTRACT Reversible transcriptional silencing of genes located near telomeres, termed the telomere position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been observedExpand
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Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells
ABSTRACT Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangementsExpand
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Hyperthermia and irradiation of head and neck squamous cancer cells causes migratory profile changes of tumour infiltrating lymphocytes
Purpose: CD4+CD25+FoxP3+ regulatory T-cells (Treg) are responsible for immunoevasion mechanisms induced by cancer. Specific chemokines such as CCL22 are presumed to mediate active Treg traffickingExpand
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Promoter independent down-regulation of the firefly luciferase gene by T3 and T3 receptor in CV1 cells
We report that the activity of the firefly luciferase (LUC) reporter gene is down-regulated by T3 and T3 receptor (TR) in the CV1 mammalian cell line, which is widely used for studies of TR action.Expand
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N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays
STUDY QUESTION Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER N-cadherinExpand
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Effect of telomere length on telomeric gene expression.
Telomeres gradually shorten as human somatic cells divide and a correlation has been observed between the average telomere length and cell senescence. It has been proposed that the genes responsibleExpand
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  • Open Access
Genome-Wide Transcription Responses to Synchrotron Microbeam Radiotherapy
The majority of cancer patients achieve benefit from radiotherapy. A significant limitation of radiotherapy is its relatively low therapeutic index, defined as the maximum radiation dose that causesExpand
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Normal telomere maintenance in immortal ataxia telangiectasia cell lines.
Telomeres are maintained in germ line cells and immortal cell lines, but shorten with each cell division in most somatic cells. Blood lymphocytes from individuals with ataxia telangiectasia (AT)Expand
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Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line.
We examined phosphorylation of H2AX, a marker for DNA double-strand breaks over the life of a human fibroblast cell line. This marker was compared with a number of other cellular senescence and DNAExpand
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