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Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
The biosynthesis and release of nitric oxide (NO) and prostaglandins (PGs) share a number of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) enzymes have beenExpand
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A Newly Identified Role for Superoxide in Inflammatory Pain
Novel classes of pain-relieving molecules are needed to fill the void between nonsteroidal anti-inflammatory agents and narcotics. Our studies have identified superoxide as a novel mediator ofExpand
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Regulation of uric acid metabolism and excretion.
Purines perform many important functions in the cell, being the formation of the monomeric precursors of nucleic acids DNA and RNA the most relevant one. Purines which also contribute to modulateExpand
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On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
The list of pathophysiological conditions associated with the overproduction of superoxide expands every day. Much of the knowledge compiled on the role of this radical in disease has been gatheredExpand
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Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats andExpand
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Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain
Chemotherapy-induced peripheral neuropathy (CIPN) accompanied by chronic neuropathic pain is a major dose-limiting side effect of a large number of antitumoral agents including paclitaxel (Taxol).Expand
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SUPEROXIDE POTENTIATES NF-κB ACTIVATION AND MODULATES ENDOTOXIN-INDUCED CYTOKINE PRODUCTION IN ALVEOLAR MACROPHAGES
Gram-negative bacterial infection predisposes to the development of shock and acute lung injury with multiple organ dysfunction in the critically ill. Although overexpression of proinflammatoryExpand
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Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-d-aspartate-mediated hyperalgesia
&NA; N‐methyl‐d‐aspartate (NMDA) receptors serve prominent roles in vast physio‐pathological conditions including hyperalgesia (defined as augmented pain intensity in response to painful stimuli)Expand
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Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
Severe pain syndromes reduce quality of life in patients with inflammatory and neoplastic diseases, often because chronic opiate therapy results in reduced analgesic effectiveness, or tolerance,Expand
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The effect of nitric oxide on cytokine‐induced release of PGE2 by human cultured astroglial cells
The role of the L‐arginine‐nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin‐1β (IL‐1β) and tumour necrosis factor‐αExpand
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