C. Murphy

Publications229
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Citations4,031
Highly Influential Citations112
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Uterine receptivity and the plasma membrane transformation
ABSTRACTThis review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine…
Redistribution of aquaporins 1 and 5 in the rat uterus is dependent on progesterone: a study with light and electron microscopy.
TLDR
Results, for the first time, show that the up-regulation of AQP5 in the apical plasma membrane of uterine epithelial cells and AQP1 in the inner circular layer of myometrium, is dependent on progesterone.
Redistribution of aquaporins in uterine epithelial cells at the time of implantation in the rat.
CALCIUM TRANSPORT ACROSS THE UTERINE EPITHELIUM OF PREGNANT LIZARDS
TLDR
The findings suggest that the down regulation of Ca2+ATPase in the shell glands may be an important contributor to the evolution of viviparity through the loss of an eggshell.
Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles.
TLDR
No relevant alteration was observed in the endometrial development in the early and mid-luteal phases in women undergoing controlled ovarian stimulation for oocyte donation following daily treatment with a standard- or high-dose GnRH antagonist.
Interleukin-1 receptor antagonist prevents embryonic implantation by a direct effect on the endometrial epithelium.
Aquaporins are upregulated in glandular epithelium at the time of implantation in the rat
TLDR
The presence of AQPs5 and 9 in the apical plasma membrane of the glandular epithelium seen in this study provides a mechanism for transcellular fluid transport across these glandular endothelial cells similar to that seen in luminal epithelial cells.
Alterations in tight junction molecules of uterine epithelial cells during early pregnancy in the rat.
TLDR
It is shown that ZO-1, claudin-1 and occludin are present in the apical region of uterine epithelial cells, and appear to play a role in the very dynamic tight-junctional network of uterin epithelial Cells during early pregnancy.
Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma.
Focal adhesions disassemble during early pregnancy in rat uterine epithelial cells
TLDR
Observations suggest that uterine epithelial cells are less adherent to the underlying basal lamina due to the disassembly of talin and paxillin from focal adhesions, facilitating removal of these cells at the time of implantation.
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