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Novel galactosylated liposomes for hepatocyte-selective targeting of lipophilic drugs.
Newly developed galactosylated liposomes have been proven to be a useful carrier for hepatocyte-selective targeting that will have many practical applications.
Targeted Delivery of Prostaglandin E1 to Hepatocytes Using Galactosylated Liposomes
Prostaglandin E1 was incorporated in galactosylated liposomes containing cholesten-5-yloxy-N-(4-((1-imino-2-β-D-thiogalactosylethyl)amino)butyl)formamide intended for hepatocyte-selective delivery to suppress the GPT increase in mice with fulminant hepatitis induced by peritoneal injection of carbon tetrachloride.
Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil.
There was a dose-dependent increase in miR-122 after administration of APAP intraperitoneally and the expression of miR -122 increased in a more rapid manner compared to ALT activity, and the degree of AILI was not changed by the use of 5-fluorouracil in combination with APAP in mice.
Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles
The time-course pharmacokinetics of the two hydrophilic drugs after the brain delivery with bubble formulations and ultrasound irradiation using mice and rats were clarified.
[Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections].
Compatibility was not observed in non-pH-adjusted VCM with Lasix®, injections, but white crystals appeared when VCM injections adjusted to pH 2.5 experimentally were mixed with a Lasix® injection, suggesting that the acidic condition of V CM injections cause compatibility.