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Lymphocyte‐Selective Cytostatic and Immunosuppressive Effects of Mycophenolic Acid in Vitro: Role of Deoxyguanosine Nucleotide Depletion
- E. Eugui, S. Almquist, C. Muller, A. Allison
- Medicine, Biology
- Scandinavian journal of immunology
- 1 February 1991
Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B… Expand
Quercetin and naringenin transport across human intestinal Caco‐2 cells
Objectives Flavonoids are phenolic compounds found in most edible fruits and vegetables. Previous studies have demonstrated their biological and beneficial effects on human health. However, their… Expand
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation
- M. Krifa, M. Alhosin, +6 authors M. Mousli
- Biology, Medicine
- Journal of experimental & clinical cancer…
- 20 May 2013
Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of… Expand
Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease.
BACKGROUND: Increasing evidence points to a important role for inflammatory cytokines for the pathogenesis of Crohn's disease. AIM: To compare the secretion rate of tumour necrosis factor-alpha… Expand
Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease
Chronic inflammation in inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) may be attributed partly to increased secretion of inflammatory cytokines. The aim of this study was… Expand
Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.
The salvage anti-tumoral pathway which implicates the p53-related p73 gene is not yet fully characterized. We therefore attempted to identify the up- and down-stream events involved in the activation… Expand
Quercetin and naringenin transport across human intestinal Caco-2 cells.
- Meriem Nait Chabane, A. Al Ahmad, J. Peluso, C. Muller, G. Ubeaud
- The Journal of pharmacy and pharmacology
OBJECTIVES Flavonoids are phenolic compounds found in most edible fruits and vegetables. Previous studies have demonstrated their biological and beneficial effects on human health. However, their… Expand
Mechanisms of Action of Mycophenolic Acid
In vitro effects of oxpentifylline on inflammatory cytokine release in patients with inflammatory bowel disease.
BACKGROUND: Inflammatory cytokines, including tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1 beta, have been implicated as primary mediators of intestinal inflammation in… Expand
Major bioactivities and mechanism of action of essential oils and their components
Essential oils are gaining increasing interest for their antimicrobial and antiviral properties, as well as for their preventive and therapeutic actions against many human pathologies. Herein, we… Expand