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Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants.
TLDR
It is demonstrated that the antidepressants tianeptine and, to a lesser extent, fluoxetine are able to reverse the impairment in LTP, a measure of frontal synaptic plasticity, caused by stress on an elevated platform. Expand
Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine
TLDR
The results of this study point to the importance of understanding the mechanism for the differential and subregional regulation of GLT-1 isoforms in neuronal and glial compartments in the hippocampus as a basis for understanding the effects of chronic stress on structural plasticity as well as the neuroprotective properties of agents such as tianeptine. Expand
Differential effects of predator stress and the antidepressant tianeptine on physiological plasticity in the hippocampus and basolateral amygdala
TLDR
The hypothesis that acute stress impairs hippocampal functioning and enhances amygdaloid functioning is supported with the finding that tianeptine administered under non-stress conditions enhanced electrophysiological measures of plasticity in the hippocampus and amygdala under stress, as well as non- stress, conditions. Expand
Behavioral effects of pre- and postnatal exposure to a mixture of low chlorinated PCBs in rats.
TLDR
It is concluded that in rats PCB exposure causes consistent alterations in all of the tested activity-dependent behaviors. Expand
Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress
TLDR
The findings indicate that treatment with tianeptine, unlike propanolol, provides an effective means with which to block the adverse effects of stress on cognitive functions of the hippocampus. Expand
The AMPA modulator S 18986 improves declarative and working memory performances in aged mice
TLDR
The memory-enhancing properties of S 18986 are confirmed and, in line with emerging data on multiple AMPA modulators, the relevance of targeting AMPA receptors in the development of new memory enhancers is highlighted. Expand
Neuronal depletion of the amygdala resembles the learning deficits induced by low level lead exposure in rats.
TLDR
The results suggest an involvement of the amygdala in the neurotoxic action of lead, but not as the only brain structure, and deficits in permanently lead-exposed rats are more pronounced than in only maternally-exp exposed animals suggesting a longlasting,but not totally irreversible effect of early lead exposure. Expand
Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging
TLDR
Chronic, oral administration of S18986 increases locomotor activity and performance in a spatial memory task in aged rodents and attenuates the age-related increase in the expression of a microglial marker in the hippocampus, providing a framework for further studies of the potentially beneficial effects of AMPAR modulators on brain aging. Expand
DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA‐Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer
TLDR
S 18986, a new selective positive allosteric modulator of AMPA‐type glutamate receptors, increased induction and maintenance of LTP in the hippocampus as well as the expression of brain‐derived neurotrophic factor (BDNF) both in vitro and in vivo. Expand
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