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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
TLDR
This work has identified truncating mutations in TARBP2 (TAR RNA-binding protein 2), encoding an integral component of a DICER1-containing complex, in sporadic and hereditary carcinomas with microsatellite instability, and provides an explanation for the observed defects in the expression of mature miRNAs. Expand
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.
TLDR
The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features. Expand
Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
TLDR
It is discovered that the miR-200 epigenetic silencing is not an static and fixed process but it can be shifted to hypermethylated or unmethylated 5′-CpG island status corresponding to the EMT and MET phenotypes, respectively. Expand
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
TLDR
The small molecule enoxacin, a fluoroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by binding to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP). Expand
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.
TLDR
The development of a DNA methylation based assay can significantly improve diagnoses of cancer of unknown primary and guide more precise therapies associated with better outcomes. Expand
Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.
TLDR
A novel resistance mechanism is described in BRCA1-methylated PDX tumors involving de novo rearrangements at the BRC a1 locus, demonstrating that BRCa1- methylated breast cancers may acquire therapy resistance via both epigenetic and genetic mechanisms. Expand
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation
TLDR
A previously unidentified regulatory phenomenon underlying the transcriptional activation of the intermediate filament protein vimentin is discovered and R-loop–mediated enhancement of gene expression involving head-to-head antisense transcription at a cancer-related locus is described. Expand
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
TLDR
The findings identify SETDB1 as a bona fide oncogene undergoing gene amplification-associated activation in lung cancer and suggest its potential for new therapeutic strategies. Expand
Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer
TLDR
Objective clinical responses to dacarbazine in patients with metastatic CRC are confined to those tumors harboring epigenetic inactivation of the DNA repair enzyme MGMT. Expand
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