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Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells.
TLDR
Examination of unirradiated cultures 48 h after receiving irradiated medium revealed the presence of high numbers of apoptotic bodies and other morphological evidence suggesting apoptosis may be a prominent mechanism of cell death responsible for the reduced cloning efficiency.
Relative Contribution of Bystander and Targeted Cell Killing to the Low-Dose Region of the Radiation Dose–Response Curve
TLDR
Data are presented showing a method of correcting the overall survival curve to enable analysis of the relative contributions of the bystander effect and the effect attributable to direct interaction of the radiation with the target cell.
Radiation-Induced Bystander Effects: Past History and Future Directions
TLDR
A review of the history of bystander effects in the earlier literature, in which the clastogenic effect of plasma from irradiated patients was well known, and the effect was known to persist for several years and to cause transgenerational effects, similar to what the authors now call genomic instability.
The Involvement of Calcium and MAP Kinase Signaling Pathways in the Production of Radiation-Induced Bystander Effects
TLDR
Investigation of MAPK signaling pathways in bystander cells exposed to irradiated cell conditioned medium found reactive oxygen species, such as superoxide and hydrogen peroxide, and calcium signaling were found to be important modulators of bystander responses.
Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis
TLDR
The data suggest that initiating events in the apoptotic cascade were induced in unexposed cells by a signal produced by irradiated cells.
Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into
TLDR
It was found that the degree of cell-cell contact had no effect on the ability of medium from irradiated epithelial cell cultures to reduce the clonogenic survival of unirradiated cells, and inhibition of gap junction intercellular communication using the tumor promoter phorbol myristate acid (PMA), which closes gap junctions, increased killing by the bystander effect.
Radiation-induced bystander effects — implications for cancer
TLDR
There is strong evidence for a chemical signalling process that transmits information from the irradiated cell to neighbouring cells, which has several important implications for radiation protection, radiotherapy and diagnostic radiology.
Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition
TLDR
The authors suggest that the lack of correlation observed between G2 and G0 chromosomal radiosensitivity, also observed by Scott et al (1994), could be attributable to different DNA damage processing mechanisms operating in the G0 and G2 phase of the cell cycle.
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