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An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
CDK4/CDK6 and RB proteins drive the progression through the G1 phase of the cell cycle. In acute myeloid leukemia (AML), the activity of the CDK/Cyclin D complex is increased. The mechanism involvedExpand
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The role of mechanical stretching in the activation and localization of adhesion proteins and related intracellular molecules
The molecular complexity of the processes which lead to cell adhesion includes membrane and cytoskeletal proteins, involved in the focal adhesion formation, as well as signaling molecules tightlyExpand
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