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Polyphenols: food sources and bioavailability.
- C. Manach, A. Scalbert, C. Morand, C. Rémésy, L. Jiménez
- BiologyAmerican Journal of Clinical Nutrition
- 1 May 2004
The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
- C. Manach, G. Williamson, C. Morand, A. Scalbert, C. Rémésy
- MedicineAmerican Journal of Clinical Nutrition
Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
Dietary Polyphenols and the Prevention of Diseases
- A. Scalbert, C. Manach, C. Morand, C. Rémésy, L. Jiménez
- Medicine, BiologyCritical reviews in food science and nutrition
- 1 June 2005
Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis, but no clear associations have been found between cancer risk and polyphenol consumption.
Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
- C. Manach, C. Morand, Á. Gil-Izquierdo, C. Bouteloup-Demange, C. Rémésy
- MedicineEuropean Journal of Clinical Nutrition
- 1 February 2003
In case of a moderate or high consumption of orange juice, flavanones may represent an important part of the pool of total polyphenols present in plasma.
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity, suggesting that hesperidin could be causally linked to the beneficial effect of orange juice.
Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
Absorption and metabolism of polyphenols in the gut and impact on health.
Bioavailability of rutin and quercetin in rats
Catechin is metabolized by both the small intestine and liver of rats.
The roles of the rat small intestine in the glucuronidation and methylation of flavonoids as well as the role of the liver in sulfation, methylation and biliary excretion are demonstrated.
Plasma metabolites of quercetin and their antioxidant properties.
- C. Morand, V. Crespy, C. Manach, C. Besson, C. Demigné, C. Rémésy
- Biology, ChemistryAmerican Journal of Physiology. Regulatory…
- 1 July 1998
This study shows that ubiquitous quercetin is conjugated in vivo, yielding metabolites that exhibit antioxidant properties, thus the health benefits of flavonoids in foods can be due to the antioxidant properties of their metabolites.