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NASH limits anti-tumour surveillance in immunotherapy-treated HCC
TLDR
The progressive accumulation of exhausted, unconventionally activated CD8+PD1+ T cells in NASH-affected livers provides a rationale for stratification of patients with HCC according to underlying aetiology in studies of immunotherapy as a primary or adjuvant treatment.
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.
TLDR
Tumors classified within the Metabolic class showed a hepatocyte-like phenotype with activation of the transcription factor HNF4A and enrichment in gene signatures related to bile acid metabolism, and tumors in the Immune class had a higher lymphocyte infiltration, overexpression of PD-1/PD-L1 and molecular features associated with a better response to immune checkpoint inhibitors.
Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C
TLDR
In conclusion, SVR post‐LT induces fibrosis regression in most patients, leading to significant clinical benefits and LSM accurately predicts the presence of AF and PH 1 year after SVR and thus can be used to determine monitoring strategies.
Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury.
TLDR
Liver endothelial cells are the first liver cell type affected after any kind of liver injury and their unique phenotype during injury amplifies liver damage by orchestrating the response of the liver microenvironment and its manipulation can modify the progression of liver damage.
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
TLDR
This study demonstrates that IGF-1R nuclear location might lead to chemotherapy and targeted agent resistance in patients with metastatic colorectal cancer, and significantly correlated with poor overall survival in mCRC patients.
Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma
TLDR
LN pooling makes it possible to analyze a high number of LNs from surgical colectomies with few molecular tests per patient and provides a more accurate LN pathological staging with potential prognostic implications.
Oropharyngeal Syphilis: Imaging and Pathologic Findings in Two Patients
TLDR
Two cases of oropharyngeal syphilis in two middle-aged men who presented with a painless tonsillar ulcer and progressive enlargement of cervical lymph nodes suspected of being atonsillar tumour are presented.
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
TLDR
It is shown for the first time that liver hCPT1AM gene therapy in a mouse model of established obesity, diabetes, and NAFLD can reduce HFD‐induced derangements and highlights TAG (C50:1) as a potential noninvasive biomarker that might be useful to monitorNAFLD in mice and humans.
Endoscopic tattooing of early colon carcinoma enhances detection of lymph nodes most prone to harbor tumor burden
TLDR
Endoscopic endoscopic tattooing enables the analysis of those LNs most prone to harbor tumor cells and improves the number of LN harvested, as well as molecular detection of occult LN tumor burden in histologically pN0 CRC patients.
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
TLDR
An immune-related gene expression pattern in liver tissues of patients with early-stage HCC, called the ICF, is identified that associates with risk of HCC development in patients with cirrhosis.
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