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The TRP Superfamily of Cation Channels
  • C. Montell
  • Biology, Medicine
  • Science's STKE
  • 22 February 2005
Members of the TRP superfamily function in various processes, although their roles are best established in sensory modalities ranging from vision to hearing, taste, pheromone detection, pain perception, and osmosensation, which have relevance for human health. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
The TRP Channels, a Remarkably Functional Family
TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes for regulating ion channels. Moreover, theExpand
Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction
In situ hybridizations of norpA cDNA to adult tissue sections show that this gene is expressed abundantly in the retina and that PLC is an essential component of the Drosophila phototransduction pathway. Expand
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction
Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells and encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Expand
repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system.
The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development, and Expression of repo appeared to be specific to glia throughout development. Expand
A Drosophila Gustatory Receptor Essential for Aversive Taste and Inhibiting Male-to-Male Courtship
The requirements for GR33a, which is expressed widely in gustatory receptor neurons (GRNs) that respond to aversive chemicals, are described, and it is suggested that it may be a coreceptor required for sensing all nonvolatile repulsive chemicals, including tastants and pheromones. Expand
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
At present, no features, other than overall 6TM architecture/homology and cationic permeability, define the TRP family, and the definition of TRP channels will evolve as functions and structures are clarified. Expand
TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel
It is demonstrated that TRPM5 and TRPM4b represent the first examples of voltage-modulated, Ca(2+)-activated, monovalent cation channels (VCAMs), and the voltage modulation and rapid kinetics provideTRPM5 with an excellent set of properties for participating in signaling in taste receptors and other excitable cells. Expand
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6.
It is proposed that regulation of CaM binding by PIs provides a mode for integration of channel regulation by Ca(2+) and PIs and is applied to other TRP channels, such as TRPV1, as well as to the voltage-gated channels KCNQ1 and Ca(v)1. Expand