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The TRP Superfamily of Cation Channels
  • C. Montell
  • Biology, Medicine
  • Science's STKE
  • 22 February 2005
The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation channels that bear structural similarities to Drosophila TRP. TRP channels play important roles inExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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The TRP Channels, a Remarkably Functional Family
TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes for regulating ion channels. Moreover, theExpand
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Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction
Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequentExpand
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repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system.
We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of theExpand
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TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel
The TRPM subfamily of mammalian TRP channels displays unusually diverse activation mechanisms and selectivities. One member of this subfamily, TRPM5, functions in taste receptor cells and has beenExpand
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A Drosophila Gustatory Receptor Essential for Aversive Taste and Inhibiting Male-to-Male Courtship
Contact chemosensation is required for several behaviors that promote insect survival. These include evasive behaviors such as suppression of feeding on repellent compounds, known as antifeedants,Expand
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International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
include a 25-amino acid (aa) motif in some subfamilies (the TRP domain) containing a TRP box (EWKFAR) just C-terminal to S6. The TRP domain and box, as well as slight variations of these motifs, areExpand
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TRPC1, a human homolog of a Drosophila store-operated channel.
In many vertebrate and invertebrate cells, inositol 1,4,5-trisphospate production induces a biphasic Ca2+ signal. Mobilization of Ca2+ from internal stores drives the initial burst. The second phase,Expand
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Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6.
Multiple TRP channels are regulated by phosphoinositides (PIs). However, it is not known whether PIs bind directly to TRP channels. Furthermore, the mechanisms through which PIs regulate TRP channelsExpand
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