• Publications
  • Influence
Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study
Background Different amyotrophic lateral sclerosis (ALS) phenotypes have been recognised, marked by a varying involvement of spinal and bulbar upper and lower motor neurons. However, the differentialExpand
  • 319
  • 19
A longitudinal study on quality of life and depression in ALS patient–caregiver couples
Objectives: To evaluate the modification of quality of life (QoL) and depression in a series of amyotrophic lateral sclerosis (ALS) patient–caregiver couples during a period of 9 months and compareExpand
  • 212
  • 16
Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy
Background There is less data available regarding the characteristics of cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) in a population-based series. Methodology PatientsExpand
  • 179
  • 14
  • PDF
Neurobehavioral symptoms in ALS are negatively related to caregivers’ burden and quality of life
Objective:  To evaluate the frequency of neurobehavioral symptoms related to FTLD in a consecutive series of amyotrophic lateral sclerosis (ALS) patients and to assess their influence on patients’Expand
  • 118
  • 10
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALSExpand
  • 268
  • 8
  • PDF
Pain in amyotrophic lateral sclerosis: a population‐based controlled study
Background and purpose:  To assess the prevalence and characteristics of pain in an epidemiological series of patients with amyotrophic lateral sclerosis (ALS) compared to population‐based controls.
  • 62
  • 7
Lower serum lipid levels are related to respiratory impairment in patients with ALS
Background: Recently hyperlipidemia was reported to be related to a significantly better outcome in amyotrophic lateral sclerosis (ALS). To investigate this, we evaluated the status of blood lipidsExpand
  • 123
  • 6
Anxiety undermines quality of life in ALS patients and caregivers
Background:  Although depression has been widely studied in amyotrophic lateral sclerosis (ALS), there is little information on anxiety.
  • 70
  • 6
Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset
PurposeTo identify the neurobiological traits of amyotrophic lateral sclerosis (ALS) and to elucidate functional differences between ALS of spinal and bulbar onset. We hypothesized that glucoseExpand
  • 114
  • 4
  • PDF
Extensive genetics of ALS
Objective: To assess the frequency and clinical characteristics of patients with mutations of major amyotrophic lateral sclerosis (ALS) genes in a prospectively ascertained, population-basedExpand
  • 100
  • 4