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MGMT Promoter Methylation and Glioblastoma: A Comparison of Analytical Methods and of Tumor Specimens
- L. Lattanzio, Marzia Borgognone, +11 authors C. L. Nigro
- The International journal of biological markers
- 1 April 2015
It is already well known that hypermethylation of the O6-methylguanine DNA methyltransferase (MGMT) gene promoter is a predictive biomarker of response to temozolomide treatment and of favorable… Expand
MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors
MGMT (O6-methylguanine-DNA methyltransferase) promoter hypermethylation is a helpful prognostic marker for chemotherapy of gliomas, although with some controversy for low-grade tumors. The objective… Expand
Physiologic modulation of natural killer cell activity as an index of Alzheimer's disease progression
Patients with Alzheimer's disease (AD) are characterized by an altered sensitivity to cortisol-mediated modulation of circulating lymphocytes. Longitudinal studies are needed to address the clinical… Expand
Wernicke-Korsakoff syndrome, associated with acute axonal polyneuropathy, induced by hyperemesis gravidarum
Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
The emerging domain of epigenetics in molecular medicine finds application for a variety of patient populations. Here, we present fundamental neuroendocrine immune evidence obtained in patients with… Expand
Incidence of primary central nervous system lymphomas does not increase in the late 1990s-early 2000s
Frequency, patterns of care, and outcome of neoplastic meningitis (NM) from solid tumors in regione Piemonte, Italy: A prospective survey from a cancer network.
e12530 Background: Neoplastic meningitis (NM) is a devastating neurologic complication of cancer whose frequency and patterns of care are not well known. We investigated in a prospective survey the… Expand
Abstract 4432: Low miR-222 expression levels predict long-term survival of patients affected by glioblastoma
Association of Supratotal Resection with Progression-Free Survival, Malignant Transformation, and Overall Survival in Lower-Grade Gliomas.
BACKGROUND supratotal resection is advocated in lower-grade-gliomas (LGGs) based on theoretical advantages, but with limited verification of functional risk and data on oncological outcomes. We… Expand
Effect of Brivaracetam on Efficacy and Tolerability in Patients With Brain Tumor-Related Epilepsy: A Retrospective Multicenter Study
Background: Epilepsy is a common symptom of brain tumors and is often pharmacoresistent. Among new antiseizure medications (ASMs) Brivaracetam (BRV) has been approved as adjunctive treatment for… Expand