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Vero-cell rabies vaccine produced using serum-free medium.
TLDR
The effective immunogenicity induced in mice by this vaccine, the degree of purity of the product, the high antigen yield and the reduction of the cost of the products due to the virus production and purification processes, makes this technology very important for countries where rabies presents a great public health problem. Expand
Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice.
TLDR
Results indicate that a more favorable profile of both humoral and cell-mediated immune responses may be obtained using the MPLA/Al(OH)(3) formulation, which led to the induction of the highest IgG levels together with the secretion of both IFN-gamma and IL-4. Expand
[Mycoplasma as a contaminant of cell cultures maintained in laboratories of private and official institutions].
TLDR
The aim of this study was to verify the incidence of mycoplasma in cell lines maintained in seven laboratories of private, government and college institutions of the State of São Paulo, Brazil, for the purposes of research, production of reagents for diagnosis and production of biologicals for human and animal use. Expand
Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations.
TLDR
Consecutive lots of H5N1 (A/Vietnam/1194/2004 - NIBRG-14) split virion and whole virus vaccines were produced in a pilot-scale laboratory and dose sparing strategies using adjuvant formulations using aluminum hydroxide (Al(OH)(3)) and monophosphoryl lipid A from Bordetella pertussis were tested in mice. Expand
Influenza vaccine production for Brazil: a classic example of successful North-South bilateral technology transfer.
TLDR
It is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majority of these countries to face the huge demand for vaccine created by influenza pandemics. Expand
Sorbitol-gelatin and glutamic acid-lactose solutions for stabilization of reference preparations of measles virus.
TLDR
Results indicate that sorbitol-gelatin, used under the conditions of this study, is an effective stabilizer in the preparation of freeze-dried suspensions of Schwarz strain measles virus employed as reference preparation working lots. Expand
Vitamins as influenza vaccine adjuvant components
TLDR
Of the 27 adjuvant combinations, MPLA with alum and B2 with alum were the most promising adjuvants to be evaluated in humans. Expand
[Susceptibility of Vero cell line to vaccine strains of the measles virus].
TLDR
It is suggested that all control laboratories should use the same protocols for cell culture maintenance as well as for vaccine potency testing, to minimize the differences existing among the results obtained in the potency testing. Expand
Study on the growth promotion capacity of calf serum for animal cells in vitro.
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