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Fine Pathogen Discrimination within the APL1 Gene Family Protects Anopheles gambiae against Human and Rodent Malaria Species
TLDR
Functional analysis of the joint response of APL1 family members during mosquito infection with human and rodent Plasmodium species reveals that mosquito innate immunity possesses a more fine-grained capacity to distinguish between classes of closely related eukaryotic pathogens than has been previously recognized. Expand
Plant Insecticide L-Canavanine Repels Drosophila via the Insect Orphan GPCR DmX
TLDR
These findings show that the DmX receptor, which does not belong to the Gr family, fulfills a gustatory function necessary to avoid eating a natural toxin. Expand
Divergent Evolution in Metabotropic Glutamate Receptors
TLDR
It is found that the DmX receptor was activated by a ligand containing an amino group, which was extracted from Drosophila head and from other insects (Anopheles and Schistocerca) and indicates that the LBP of the mGluRs has diverged in insects to recognize a new ligand. Expand
Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota
TLDR
It is found that important immune mechanisms involved in the first bottleneck to Anopheles infection, the midgut, have distinct effects on arbovirus or malaria, the first concrete evidence of protection tradeoffs for different human pathogens in a human disease vector. Expand
Gαo Is Required for L-Canavanine Detection in Drosophila
TLDR
This study revealed that Gαo47A plays a crucial role in L-canavanine detection, a variant G-protein coupled receptor belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila. Expand
Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implications for memory formation
TLDR
It is shown that the honeybee genome encodes a genuine mGluR (AmGluRA) that is expressed at low to medium levels in both pupal and adult brains, and the notion that glutamate is a key neurotransmitter in memory processes in the honeybees is strengthened. Expand
The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing
TLDR
Genetic variation influencing Plasmodium infection in wild Anopheles is linked to a natural ~3 megabase haplotype on chromosome 2L that carries the kdr allele of the para gene, which may be linked to increased parasite infection prevalence. Expand
Diverged Alleles of the Anopheles gambiae Leucine-Rich Repeat Gene APL1A Display Distinct Protective Profiles against Plasmodium falciparum
TLDR
The structure of the APL1 locus is exhaustively characterized and it is shown that three structurally differentAPL1A alleles segregate in the Ngousso colony, suggesting that APL 1A genetic variation could be a factor underlying natural heterogeneity of vector susceptibility to P. falciparum. Expand
Density-dependent impact of the human malaria parasite Plasmodium falciparum gametocyte sex ratio on mosquito infection rates
TLDR
In vitro transmission studies of P. falciparum to Anopheles gambiae mosquitoes find that there is a discernible effect of sex ratio on transmission but which is dependent upon the gametocyte density, and empirical confirmation that sex ratio has an immediate impact on transmission success and that it is density-dependent. Expand
Anopheles Gambiae PRS1 Modulates Plasmodium Development at Both Midgut and Salivary Gland Steps
TLDR
The results reveal that PRS1 likely contributes to fundamental interactions between Plasmodium and mosquito epithelia, which do not depend on the specific Anopheles/P. Expand
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